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Saudi Journal of Kidney Diseases and Transplantation
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SPECIAL ARTICLE Table of Contents   
Year : 1994  |  Volume : 5  |  Issue : 4  |  Page : 466-469
Pathogenesis of growth failure in renal diseases

1 Department of Pediatrics, Postgraduate Medical Institute, Lahore, Pakistan
2 Department of Pediatrics, Hunan Medical University, Hunan, People's Republic of China, China
3 Nephrology Division, Children's Medical Center, Richmond, Virginia, USA

Correspondence Address:
James CM Chan
MCV Station, Box 498, Richmond, VA 23298-0498
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PMID: 18583772

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This article reviews our current understanding of the mechanisms of growth failure in chronic renal disease. The neuro-endocrine control of growth hormone secretion and insulin-like growth factor gene expression subject to use of corticosteroids, uremia, and metabolic acidosis are presented. It has been shown in other non-growth hormone deficient conditions such as Turner's syndrome that the use of exogenous growth hormone increases linear growth but also accelerates closure of the growth plate with no significant difference in the final height of such children. An understanding of growth factors is especially important and timely because of the tendency these days to use growth hormone to overcome the growth impairment of children with chronic renal failure.

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