Home About us Current issue Back issues Submission Instructions Advertise Contact Login   

Search Article 
  
Advanced search 
 
Saudi Journal of Kidney Diseases and Transplantation
Users online: 914 Home Bookmark this page Print this page Email this page Small font sizeDefault font size Increase font size 
 

LETTER TO THE EDITOR Table of Contents   
Year : 1995  |  Volume : 6  |  Issue : 1  |  Page : 53-54
Idiopathic Focal and Segmental Glomerulosclerosis


Hamad General Hospital, Doha, Qatar

Click here for correspondence address and email
 

How to cite this article:
Akl K. Idiopathic Focal and Segmental Glomerulosclerosis. Saudi J Kidney Dis Transpl 1995;6:53-4

How to cite this URL:
Akl K. Idiopathic Focal and Segmental Glomerulosclerosis. Saudi J Kidney Dis Transpl [serial online] 1995 [cited 2020 Jul 5];6:53-4. Available from: http://www.sjkdt.org/text.asp?1995/6/1/53/40900
Dear Sir,

With interest I read the article by Singh et al "Ten years follow-up of idiopathic focal and segmental glomerulosclerosis" [1] .

The authors combined children with adults even though there are differences in the presentation, course and response to therapy. Furthermore, their definitions of proteinuria, hypertension, and remission do not apply to children. For example, a urinary protein excretion of 1 gram per 24 hours and a blood pressure of 120/80 mm Hg represent nephrotic range proteinuria and significant hypertension respectively for a one year old child. As for presentation, many children with onset of focal segmental glomerulosclerosis (FSGS) in the first year of life have a non-responsive form of this disease which is even different from that of childhood.

We have two such families with six afflicted children. In one family, the serum triglycer­ides exceeded 2000 mg% which is much higher than usual nephrotics. All three members developed renal failure in two-three years after onset. The significance of the hyperlipidemia in pathogenesis and whether it may serve as a marker for the disease remains to be known.

Regarding therapy, the authors, administered alternate day steroids for eight weeks only. In a recent report by Banfi, et al, out of 59 adult nephrotics with FSGS, 27 patients received steroids alone, 19 received oral steroids with immunosuppression, and 13 had immunosuppression alone [2] . Steroids were given for 6 to 9 months in a dose of 0.5-1.0 mg/kg/day. Among the whole group, 61% responded. Only 5.5% of patients who responded to therapy developed renal failure as compared to 70% among non­responders [2] .

 
   References Top

1.Singh RG, Agarwal DK, Usha et al. Ten years follow-up of idiopathic focal and segmental glomerulosclerosis. Saudi J Kidney Dis Transplant 1994;5(3):354-8.  Back to cited text no. 1    
2.Banfi G, Moriggi M, Sabadini E, et al. The impact of prolonged immunosuppression on the outcome of idiopathic focal-segmental glomerulosclerosis with nephrotic syndrome in adults. A collaborative retrospective study. Clin Nephrol 1991;36:53-9.  Back to cited text no. 2    

Top
Correspondence Address:
Kamal Akl
FAAP Consultant Pediatric Nephrologist, Hamad General Hospital, P.O. Box 3050 Doha
Qatar
Login to access the Email id


PMID: 18583844

Rights and Permissions




 

Top
 
 
    Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
    Email Alert *
    Add to My List *
* Registration required (free)  
 


 
    References
 

 Article Access Statistics
    Viewed866    
    Printed43    
    Emailed0    
    PDF Downloaded155    
    Comments [Add]    

Recommend this journal