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Saudi Journal of Kidney Diseases and Transplantation
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CASE REPORT Table of Contents   
Year : 1995  |  Volume : 6  |  Issue : 2  |  Page : 206-210
Progression of Hepatitis C Infection in a Renal Transplant Recipient: A Case Report


Department of Nephrology, Riyadh Armed Forces Hospital, Riyadh, Saudi Arabia

Correspondence Address:
Abdalla H Abdalla
Department of Renal Medicine, Riyadh Armed Forces Hospital P.O. Box 7897, Riyadh 11159
Saudi Arabia
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PMID: 18583865

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We present a patient with hepatitis C virus (HCV) infection who developed chronic active hepatitis (CAH) after renal transplantation. Alpha-interferon (a-IF) therapy was administered in view of deteriorating liver biochemistry. Liver histology at this stage showed features suggestive of chronic active hepatitis (CAH). The patient had stable graft function. Therapy with a-IF resulted in noticeable biochemical response within two weeks of commencement. An episode of steroid resistant renal allograft rejection occurred after 10 weeks of a-IF therapy which responded well to anti-lymphocyte globulin. Since then, the CAH has gradually progressed on to the development of cirrhotic changes and hepato-cellular carcinoma after 10 years following transplantation. Our case indicates that liver disease in anti­HCV positive patients can follow a serious course following renal transplantation.


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