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Saudi Journal of Kidney Diseases and Transplantation
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ORIGINAL ARTICLE Table of Contents   
Year : 1996  |  Volume : 7  |  Issue : 3  |  Page : 297-300
Thyroid Function in Children with Chronic Renal Failure

Jeddah Kidney Center, King Fahad Hospital, Jeddah, Saudi Arabia

Correspondence Address:
Nagi Abu El-Hana
Department of Nephrology, Jeddah Kidney center, King Fahd Hospital, Jeddah
Saudi Arabia
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PMID: 18417946

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This study was undertaken to test the thyroid function in non-dialyzed children with chronic renal failure (CRF). Sixteen children with CRF and 12 healthy children who served as controls were studied for their thyroid function status. We found a significant increase in the serum thyroid stimulating hormone (TSH) level and a significant decrease in serum Triiodo thyronine (T3) levels in children with CRF as compared to the healthy children (p < 0.001). No significant difference was found between children with CRF and healthy children as regards serum thyroxine (T4) and serum free T4 (FT4) (p > 0.2). There was a weak negative correlation between hemoglobin concentration and serum TSH (r = - 45) as well as between blood urea nitrogen and serum T3 (r= -0.30) in children with CRF. These results suggest that children with CRF commonly have a state of biochemical hypothyroidism although they are clinically euthyroid. Early renal transplantation is indicated to correct such metabolic defects.

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