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Saudi Journal of Kidney Diseases and Transplantation
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LETTER TO THE EDITOR Table of Contents   
Year : 1998  |  Volume : 9  |  Issue : 4  |  Page : 461
Salt Excretion and Hypertension


Hemodialysis Unit, King Fahd Central Hospital, P.O. Box 204, Gizan, Saudi Arabia

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How to cite this article:
Subramanian P T. Salt Excretion and Hypertension. Saudi J Kidney Dis Transpl 1998;9:461

How to cite this URL:
Subramanian P T. Salt Excretion and Hypertension. Saudi J Kidney Dis Transpl [serial online] 1998 [cited 2020 May 29];9:461. Available from: http://www.sjkdt.org/text.asp?1998/9/4/461/39108
To the Editor:

Wardle [1] has provided wealth of information on certain molecular aspects for the pathogenesis of hypertension in experimental animals in a concise and understandable manner.

Though Wardle confines his discussion to salt excretion and hypertension in experimental animals, it is worth to recalling the effects of central nervous system and Y chromosome on blood pressure in these spontaneously hyper­tensive rats (SHR).

a) Budzikowski and Leenen [2] demonstrated the release of "Ouabain" in the median pre­optic nucleus, which plays a key role in the exaggeration of the hypertension in SHR by high sodium.

b) Blume and colleagues [3] have shown an enhanced sensitivity of SHR to angiotensin II-induced transcription factor expression in distinct brain areas involved in central blood pressure and osmotic control that is independent of blood pressure.

c) Results of Kreutz et al [4] in experimental animals support the relevance of Y-­chromosome effect on blood pressure and suggest that a complex interplay of epistatic and ecogenetic interaction governs its effect on phenotype. However, the observation requires confirmation with large experimental cohorts.

 
   References Top

1.Wardle EN. Salt excretion and hypertension inexperimental animals. Saudi J Kidney Dis Transplant 1997;8(4):10-13.  Back to cited text no. 1    
2.Budzikowski AS. Leenen FH. Brain "ouabain" inthe median preoptic nucleus mediates sodium-sensitive hypertension in spontaneously hypertensive rats. Hypertension 1997;29:599-605.  Back to cited text no. 2    
3.Blume A, Lebrun CJ; Hcrdegen T, et al. Increased brain transcription factor expression by angiotensin in genetic hypertension. Hypertension 1997;29:592-8.  Back to cited text no. 3    
4.Kreutz R, Stock P, Struk B, Lindpainter K. TheY-chromosome. The epistatic and ecogenetic interactions in genetic hypertension. Hypertension 1996;28:895-7.  Back to cited text no. 4    

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Correspondence Address:
P T Subramanian
Hemodialysis Unit, King Fahd Central Hospital, P.O. Box 204, Gizan
Saudi Arabia
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PMID: 18408320

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