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Saudi Journal of Kidney Diseases and Transplantation
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LETTER TO EDITOR Table of Contents   
Year : 1999  |  Volume : 10  |  Issue : 2  |  Page : 187
Immunoglobulin IgA Nephrology


Consultant Nephrologist, Samatah General Hospital, Samatah, Gizan, Saudi Arabia

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How to cite this article:
Subramanian P T. Immunoglobulin IgA Nephrology. Saudi J Kidney Dis Transpl 1999;10:187

How to cite this URL:
Subramanian P T. Immunoglobulin IgA Nephrology. Saudi J Kidney Dis Transpl [serial online] 1999 [cited 2020 Sep 30];10:187. Available from: http://www.sjkdt.org/text.asp?1999/10/2/187/37229
To the Editor:

I would like to thank E.N. Wardle [1] for providing enormous information on the molecular aspects of IgA nephropathy. I would like to get enlightened more on the following:

a) Protein Kinase C (PKC) is the key intermediary in the process by which transforming growth factor-beta TGF-Beta and angiotensin II promote mesangial cell matrix protein production. [2] However, this was not mentioned in Wardle's article. As Weiss and Al-Ramirez have shown the role of PKC inhibitor, will it be useful in arresting or postponing the progress if IgA nephropathy, which usually h an indolent course?

b) Chemoprophylaxis: is there a role of ACE inhibitors and/or anti-microbial prophylaxis in cases of synpharyngitis or syntonsillitis hematuria-proteinuria in order to arrest or postpone the progression of IgA nephropathy? If so, when and how long to prescribe?

 
   References Top

1.Wardle En. Understanding immunoglobulin IgA nephropathy. Saudi J Kidney Dis Transplant 1998;9(4):444-50.  Back to cited text no. 1    
2.Weiss RH. Al-Ramirez. TGF-Beta and angiotensin-II induced mesangial matrix protein secretion is mediated by protein Kinase C. Nephrol Dial Transplant 1998;13:2804-13.  Back to cited text no. 2    

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Correspondence Address:
P T Subramanian
Consultant Nephrologist, Samatah General Hospital, Samatah, Gizan
Saudi Arabia
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PMID: 18212432

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