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Saudi Journal of Kidney Diseases and Transplantation
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LETTER TO THE EDITOR Table of Contents   
Year : 1999  |  Volume : 10  |  Issue : 4  |  Page : 514-515
Osteodystrophy in chronic Renal Failure


Consultant Nephrologist, Samtah General Hospital, Samtah, Gizan, Saudi Arabia

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How to cite this article:
Subramanian P T. Osteodystrophy in chronic Renal Failure. Saudi J Kidney Dis Transpl 1999;10:514-5

How to cite this URL:
Subramanian P T. Osteodystrophy in chronic Renal Failure. Saudi J Kidney Dis Transpl [serial online] 1999 [cited 2020 May 28];10:514-5. Available from: http://www.sjkdt.org/text.asp?1999/10/4/514/37213
To the Editor:

The complex aspects of renal osteodystrophy have been simplified in an apt manner in the recent editorial. [1]

However, it is worth considering few more things:

a). With reference to a dynamic been disease, recent studies in animals demonstrated that estrogen decreases the production of bone morphogenetic protein-6. [2] thus, the hypogonadism observed in end-stage renal failure might contribute further to the pathogenesis of a dynamic bone disease in the absence of parathyroid hormone. [3]

b) Therapy with biphosphonates has been partially helpful to overcome the negative bone balance in dynamic bone disease, but contraindicated in dynamic bone disease. [4]

c). Acidification of our environment, a consequence of industrialization, contributes to increased exposure to aluminum and its hazards.

d). Last but not the least, contribution of heparin to osteoporosis has to be considered in predisposed population on maintenance hemodialysis. [6]

 
   References Top

1.D;Haese PC, Couttenye MM, DEBroe M. Osteodystrophy in chronic renal failure patients. Saudi J Kidney Dis Transplant 1998;9:397-415.  Back to cited text no. 1    
2.Rickard DJ, Hofbauer LC, Bonde SK, et al. Bone morphogenetic protein- 6 production in human osteoblastic cell lines. Selective regulation by estrogen. J Clin Invest 1998;101:413-22.  Back to cited text no. 2    
3.Hruska K. New concepts in renal osteodystrophy. Nephrol Dial Transplant 1998;13:2755-60.  Back to cited text no. 3  [PUBMED]  [FULLTEXT]
4.Nalluche HH. The possible use of biphosphonates in the treatment of renal osteodystrophy. Clin Nephrol 1992;38(Suppl 1):S87-91.  Back to cited text no. 4    
5.Mjoberg B. Aluminium induced hip fractures: a hypothesis. J Bone Joint Surg Br 1989;71:538.  Back to cited text no. 5    
6.Heparin Sodium literature. B Braun, Melsungen, Germany.  Back to cited text no. 6    

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Correspondence Address:
P T Subramanian
Consultant Nephrologist, Samtah General Hospital, Samtah, Gizan
Saudi Arabia
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PMID: 18212461

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