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Saudi Journal of Kidney Diseases and Transplantation
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LETTER TO EDITOR Table of Contents   
Year : 2002  |  Volume : 13  |  Issue : 1  |  Page : 63
Treatment of Progressive IgA Nephropathy


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How to cite this article:
Wardle E N. Treatment of Progressive IgA Nephropathy. Saudi J Kidney Dis Transpl 2002;13:63

How to cite this URL:
Wardle E N. Treatment of Progressive IgA Nephropathy. Saudi J Kidney Dis Transpl [serial online] 2002 [cited 2019 Sep 19];13:63. Available from: http://www.sjkdt.org/text.asp?2002/13/1/63/33205
To the Editor:

At the congress of the European Dialysis and Transplantation Association (EDTA) in Vienna June 2001, FM Rasche et al [1] indicate how cyclophosphamide pulse therapy com­bined with prednisolone 10 mg per day and angiotensin converting enzyme (ACE) inhibitors can decelerate loss of renal function. One could even add losartan 50 mg per day to all that. This is a safer approach than oral melphalan with prednisolone that I once used. [2] I want to say too that I no longer think that FK506 (tarcolimus) is a good agent for IgA nephropathy. As for mycophenolate mofetil one has to bear in mind that T and B lymphocytes and NK cells are all suppressed by its action. One of my earlier articles outlined various theoretical approaches. [2] More recently, mizoribine (available in Japan) looks promising. [3]



 
   References Top

1.Rasche FM, Klotz C, Jehle PM, et al. Cyclophosphamide pulse therapy arrests progression in primary IgA nephropathy. Nephrol Dial Transplant 2001 ;16(6):A60.  Back to cited text no. 1    
2.Wardle EN. Ways of treating IgA nephro­pathies. Saudi J Kidney Dis Transplant 2000;ll(3):325-33.  Back to cited text no. 2    
3.Ushiyama C, Nakamura T, Suzuki S, et al. Effect of mizoribine on serum IgE concentration in patients with IgA nephro pathy. Nephron 2001 ;87:194-5.  Back to cited text no. 3  [PUBMED]  [FULLTEXT]

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Correspondence Address:
E Nigel Wardle
81 Gloucester Avenue, Grimsby DN34 5BU, England

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