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Saudi Journal of Kidney Diseases and Transplantation
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CASE REPORT Table of Contents   
Year : 2006  |  Volume : 17  |  Issue : 4  |  Page : 564-567
Bone Marrow Transplantation for Leukocyte Adhesion Deficiency-I: Case Report


Bone Marrow Transplantation Unit, King Hussein medical center, Royal Medical Services,Amman, Jordan

Correspondence Address:
Adel Mohammed Al-wahadneh
Pediatric Immunologist, Pediatric Department King Hussein Medical Center, Royal Medical Services, P.O.Box 150 719, Amman 11115
Jordan
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PMID: 17186693

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Leukocyte adhesion deficiency type I (LAD-I) is a rare autosomal recessive immunodeficiency syndrome leading to recurrent bacterial and fungal infections. Bone marrow transplantation offers the only cure. In this report, we describe the course and outcome of bone marrow transplant in a 4 month-old female infant with LAD-I at King Hussein Medical Center, Jordan. A successful matched HLA- related allogeneic bone marrow transplantation was performed. Engraftment was demonstrated on the 12 th day. The patient developed Grade III grafts versus host disease (GVHD), veno-occlusive disease of the liver, and late onset hemorrhagic cystitis. She recovered with appropriate immune reconstitution.


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