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Saudi Journal of Kidney Diseases and Transplantation
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CASE REPORT Table of Contents   
Year : 2007  |  Volume : 18  |  Issue : 4  |  Page : 599-602
Crescentic Transformation in Primary Membranous Glomerulopathy: Association with Anti-GBM Antibody


Department of Nephrology, St. Johnís Medical College Hospital, Bangalore, India

Correspondence Address:
Shobhana G Nayak
Department of Nephrology, St. Johnís Medical College Hospital, Sarjapur Road, Bangalore-560034
India
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PMID: 17951950

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Crescentic transformation of primary membranous nephropathy (MN) associated with the development of anti-GBM antibody is a rare cause of acute renal failure in patients with MN. We report a 54-year-old lady, diagnosed to have MN four years earlier, who presented with acute deterioration of renal functions. Renal biopsy revealed circumferential crescents in all glomeruli. Serum anti-GBM antibodies were positive. Despite therapy with plasmapheresis, steroids and oral cyclophosphamide, she did not improve and continues to be dialysis dependent.


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