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Saudi Journal of Kidney Diseases and Transplantation
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CASE REPORT Table of Contents   
Year : 2008  |  Volume : 19  |  Issue : 3  |  Page : 450-452
Acute Interstitial Nephritis induced by Intermittent use of Rifampicin in Patient with Brucellosis


Division of Internal Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia

Correspondence Address:
S Bin Salih
Division of Internal Medicine, King Abdulaziz Medical City, P.O. Box 22490, Riyadh 11426
Saudi Arabia
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PMID: 18445910

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Acute oliguric renal failure (ARF) developed in a patient 2 days after she was started on intermittent anti-Brucella therapy including rifampicin. The clinical picture was compatible with acute allergic interstitial nephritis. Renal histology revealed mainly acute tubular necrosis with mild tubulo-intertitial mononuclear cellular infiltrate. Intermittent therapy, as in our patient, has been the major factor in the development of rifampicin induced ARF in cases reviewed in literature.


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