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Saudi Journal of Kidney Diseases and Transplantation
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RENAL DATA FROM THE ASIA - AFRICA Table of Contents   
Year : 2009  |  Volume : 20  |  Issue : 2  |  Page : 312-317
Lipid profile in post renal transplant patients treated with cyclosporine in Sudan


1 Department of Biochemistry, Faculty of Applied Medical Sciences, University of Gezira, Sudan
2 Faculty of Medicine, University of Gezira, Sudan
3 Gezira Hospital for Renal Diseases, University of Gezira, Sudan
4 Educational Development and Research Centre, University of Gezira, Sudan

Correspondence Address:
Mohamed El Imam
Urologist and Transplant Surgeon, Deputy Dean, Faculty of Medicine, University of Gezira, P.O. Box 20 Medani
Sudan
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PMID: 19237829

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Lipid profile abnormality places kidney graft recipients at an increase risk for cardiovascular diseases.This study was undertaken to determine the impact of cyclosporine A (CsA) on lipid profile of transplant patients in Gezira Hospital for Renal Diseases, Medani, Sudan. We studied 78 renal transplant patients with mean age of 42.1 years and mean transplant duration of 3.8 years. Cyclosporine A (CsA), total cholesterol (Tch), triglyceride (TG), HDL cho­lesterol (HDLch), LDL cholesterol (LDLch), and VLDL cholesterol (VLDLch) were estimated. 62.8% of the patients showed significant lipoprotein abnormalities. Renal allograft recipients showed significantly high levels of TG (p< 0.002), Tch (p< 0.00), LDLch (p< 0.01), and VLDLch (p< 0.05) compared with age and sex matched normal subjects. Increased CsA was reported in females and hypertensive patients. A significant negative correlation was noted between post­transplant duration and VLDLch. The study confirms the existence of dyslipidemia in renal trans­plant patients in our patients.


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