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Saudi Journal of Kidney Diseases and Transplantation
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Year : 2009  |  Volume : 20  |  Issue : 4  |  Page : 553-559
Renal replacement therapy in sepsis-induced acute renal failure


1 Faculty of Medicine, University of Colombo, Sri Lanka
2 Newark Hospital, Sherwood Forest NHS Trust, Newark, United Kingdom

Correspondence Address:
Senaka Rajapakse
Consultant Physician and Senior Lecturer in Medicine, Faculty of Medicine, University of Colombo
Sri Lanka
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PMID: 19587493

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Acute renal failure (ARF) is a common complication of sepsis and carries a high mortality. Renal replacement therapy (RRT) during the acute stage is the mainstay of therapy. Va­rious modalities of RRT are available. Continuous RRT using convective methods are preferred in sepsis-induced ARF, especially in hemodynamically unstable patients, although clear evidence of benefit over intermittent hemodialysis is still not available. Peritoneal dialysis is clearly inferior, and is not recommended. Early initiation of RRT is probably advantageous, although the optimal timing of dialysis is yet unknown. Higher doses of RRT are more likely to be beneficial. Use of bio­compatible membranes and bicarbonate buffer in the dialysate are preferred. Anticoagulation during dialysis must be carefully adjusted and monitored.


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