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Saudi Journal of Kidney Diseases and Transplantation
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CASE REPORT Table of Contents   
Year : 2010  |  Volume : 21  |  Issue : 1  |  Page : 135-137
Nephrotic syndrome and Guillan-barre syndrome: A rare association in child


1 Pediatric's Department, Children's Hospital of Tunis, Tunisia
2 Nephrology Department, Military Hospital, Tunis, Tunisia
3 Pediatric's Department, Charles Nicole Hospital of Tunis, Tunisia

Correspondence Address:
Olfa Bouyahia
Pediatric's Department, Children's Hospital Tunis, Tunis
Tunisia
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PMID: 20061709

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Only few cases of nephrotic syndrome associated with Guillain-Barre Syndrome (GBS) have been reported in the adult and pediatric literature. A 3-year-old boy was initially admitted to our hospital following five days of progressive weakness of his extremities, fatigue, right leg pain and numbness. There was no past history of renal or neurological disease. Cerebro­spinal fluid studies showed a protein level of 92 mg/dL and a white cell count of 1 per high-power field. The diagnosis of GBS was verified with a nerve conduction velocity test as well as. The GBS symptoms improved gradually on intravenous immunoglobulin. Three weeks later, he deve­loped severe proteinuria and edema; laboratory investigation showed nephrotic syndrome which responded to steroid therapy. Renal biopsy showed minimal change glomerulonephritis. He re­mained free of proteinuria during his 20 months of follow-up.


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