Home About us Current issue Back issues Submission Instructions Advertise Contact Login   

Search Article 
  
Advanced search 
 
Saudi Journal of Kidney Diseases and Transplantation
Users online: 1900 Home Bookmark this page Print this page Email this page Small font sizeDefault font size Increase font size 

ORIGINAL ARTICLE Table of Contents   
Year : 2010  |  Volume : 21  |  Issue : 1  |  Page : 87-92
The long-term results of pediatric patients with primary focal and segmental glomerulosclerosis


1 Department of Pediatrics, Faculty of Medicine, Ege University, Izmir, Turkey
2 Department of Pathology, Faculty of Medicine, Ege University, Izmir, Turkey

Correspondence Address:
Betul Sozeri
Department of Pediatrics, Faculty of Medicine, Ege University, Izmir
Turkey
Login to access the Email id


PMID: 20061699

Rights and Permissions

Focal and segmental glomerulosclerosis (FSGS) is a major cause of idiopathic steroid­resistant nephrotic syndrome (SRNS) and end-stage renal disease (ESRD). In this retrospective study, we report on 34 pediatric patients with FSGS who were diagnosed and treated from 1992 to 2006. The mean age at onset was 6.3 ± 4.3 years. All patients had nephrotic-range proteinuria. Micros­copic hematuria was seen in three patients and hypertension was seen in 15 patients at presentation. All patients were treated with steroids (oral and/or methylprednisolone), while 23 patients received cytotoxic therapy in addition. The mean follow-up period was 8.6 ± 3.3 years at the end of which, 59% of patients achieved complete or partial remission, 20.5% continued to have active renal di­sease while 20.5% of the patients developed CKD. Our study suggests that most of the patients with FSGS progress to renal insufficiency. Steroid therapy increases the chances of remission and pre­serves renal function in patients with sporadic primary FSGS.


[FULL TEXT] [PDF]*
Print this article  Email this article
    

  Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
   Citation Manager
  Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed5575    
    Printed87    
    Emailed0    
    PDF Downloaded868    
    Comments [Add]    
    Cited by others 7    

Recommend this journal