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Saudi Journal of Kidney Diseases and Transplantation
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ORIGINAL ARTICLE Table of Contents   
Year : 2010  |  Volume : 21  |  Issue : 2  |  Page : 295-299
Early evaluation of renal hemodynamic alterations in type I diabetes mellitus with duplex ultrasound


1 Department of Internal Medicine and Endocrinology, Center of Pediatric Nephrology and Transplantation, Cairo University, Egypt
2 Department of Pediatrics, Center of Pediatric Nephrology and Transplantation, Cairo University, Egypt
3 Vascular Laboratory, Cairo University, Egypt

Correspondence Address:
Neveen A Soliman
Professor of Pediatrics, Center of Pediatric Nephrology and Transplantation, Cairo University, Egyptian Group for Orphan Renal Diseases Cairo, 11451
Egypt
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PMID: 20228516

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To evaluate the role of renal duplex ultrasonography in the detection of early alte­ration of renal blood flow in type I diabetic patients, we studied with duplex ultrasound 32 patients with type I diabetes mellitus (19 males, 13 females, age range 8-19 years) and 35 age and sex-matched controls. The resistivity indices (RIs) and pulsatility indices (PIs) of the main renal as well as intra­renal arteries were calculated. Compared with the healthy control subjects, diabetic patients had significantly higher resistivity indices (RIs) in the intrarenal (segmental, arcuate and interlobar) ar­teries (P= 0.001). The study, also revealed a significantly positive correlation between the RIs in the intrarenal arteries in diabetics and the albumin/creatinine ratio (r= 0.54, 0.52 and 0.51 respectively), glycated hemoglobin (r= 0.61, 0.59 and 0.63 respectively), as well as the estimated GFR (e-GFR) (r= 0.53, 0.51 and 0.57 respectively). We conclude that the current study documented early intra­renal hemodynamic alterations in the form of pathologically elevated intrarenal RIs. This denotes the potential usefulness of duplex evaluation of the intrarenal arteries, as a noninvasive procedure, for monitoring type 1 diabetic patients to predict those at risk of diabetic nephropathy.


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