Home About us Current issue Back issues Submission Instructions Advertise Contact Login   

Search Article 
  
Advanced search 
 
Saudi Journal of Kidney Diseases and Transplantation
Users online: 140 Home Bookmark this page Print this page Email this page Small font sizeDefault font size Increase font size 


 
ORIGINAL ARTICLE Table of Contents   
Year : 2011  |  Volume : 22  |  Issue : 3  |  Page : 471-475
Co-administration of albumin-furosemide in patients with the nephrotic syndrome


1 Department of Nephrology, Imam-Khomeini Training Hospital, Urmia University of Medical Sciences, Urmia, Iran
2 Department of Internal Medicine, Imam-Khomeini Training Hospital, Urmia University of Medical Sciences, Urmia, Iran
3 Department of Infectious Disease, Shahid-Beheshti University of Medical Sciences, Tehran, Iran
4 Department of Internal Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
5 Students' Research Committee, Urmia University of Medical Sciences, Urmia, Iran
6 National Institute of Health Research, Tehran University of Medical Sciences, Tehran, Iran

Correspondence Address:
Nariman Sepehrvand
Imam Khomeini Hospital, UMSU, Ershad St, Urmia
Iran
Login to access the Email id


PMID: 21566302

Rights and Permissions

Generalized edema is one of the most important complications in patients with nephrotic syndrome. Diuretics like furosemide are the first choice for reducing the edema. Hypo-albuminemia reduces the effect of furosemide, and thus, this drug is co-administered with albumin to reinforce the therapeutic effect and for the correction of reduced oncotic pressure. The aim of this study was to compare urine volume and 24-hour sodium levels after using furosemide alone versus using furosemide along with albumin in patients with nephrotic syndrome. In a randomized clinical trial, ten patients with nephrotic syndrome were chosen and were randomly allocated into four groups. Three therapeutic protocols were chosen, and at the end, each patient had received all three protocols randomly. Data were gathered and analyzed using non-parametric tests in SPSS software. The average urine volume after receiving albumin alone, furosemide alone and albumin plus furosemide were 742 mL (SD = 528), 1707 mL (SD = 745) and 2175 mL (SD = 971), respectively (P = 0.015); the fractional excretion of sodium was 1.96 (SD = 0.251), 3.18 (SD = 0.25), and 4.77 (SD = 8.45), respectively (P = 0.000); the 24-hour urinary sodium levels were 18.3 (SD = 6.68), 208.4 (SD = 5.27) and 206 (SD = 8.45), respectively; while the glomerular filtration rate (GFR) was 104.5, 96.6 and 106.6 (P = 0.021), respectively, in the three therapy groups. Our study shows that albumin administration alone and with furosemide in patients with nephrotic syndrome who had normal kidney function, results in different urine volumes and sodium levels. Co-administration of albumin and furosemide increased the urine volume and sodium level, which is due to increase in the GFR as well as the diuretic effects of furosemide.


[FULL TEXT] [PDF]*
Print this article  Email this article
    

  Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
   Citation Manager
  Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed10867    
    Printed142    
    Emailed0    
    PDF Downloaded2228    
    Comments [Add]    
    Cited by others 1    

Recommend this journal