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Saudi Journal of Kidney Diseases and Transplantation
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CASE REPORT Table of Contents   
Year : 2011  |  Volume : 22  |  Issue : 3  |  Page : 521-524
Mild rhabdomyolysis after renal transplantation


Department of Urology, Tokyo Women's Medical University, School of Medicine, Tokyo, Japan

Correspondence Address:
Shoichi Iida
Department of Urology, Kidney Center, Tokyo Women's Medical University, 8-1 Kawata-Cho, Shinjuku-Ku, Tokyo 162-8666
Japan
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PMID: 21566311

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We present a kidney transplantation patient who developed rhabdomyolysis. The patient was initially immunosuppressed with tacrolimus, mycophenolate mofetil, steroids, and chimeric CD25 monoclonal antibody. He complained of severe precordial and appendicular pain on 25th day after the operation. The patient developed rhabdomyolysis manifested as a rise in serum creatine phosphkinase (CPK) and elevation of urinary myoglobulin at approximately the same time as his symptoms. Although he was switched from tacrolimus to cyclosporine (CYA), his muscle pain and levels of serum CPK did not improve. However, dividing the daily total amount of the calcinuerin inhibitors into more frequent doses in order to reach lower serum levels resolved the rhabdomyolysis. Therefore, we conclude that his rhabdomyolysis might be a dose-related problem of calcineurin inhibitor.


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