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Saudi Journal of Kidney Diseases and Transplantation
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CASE REPORT Table of Contents   
Year : 2011  |  Volume : 22  |  Issue : 4  |  Page : 792-795
ADAMTS-13 deficiency following Hemiscorpius lepturus scorpion sting


1 Department of Nephrology, Jundishapur University of Medical Sciences, Ahvaz, Iran
2 Faculty of Medicine, Jundishapur University of Medical Sciences, Ahvaz, Iran
3 Department of Pathology, Ali Asghar Children Hospital, University of Medical Sciences, Tehran, Iran

Correspondence Address:
Ehsan Valavi
Division of Nephrology, Pediatric Department, Abuzar Children's Hospital, Pasdaran St, Ahvaz
Iran
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PMID: 21743232

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Hemiscorpius lepturus is a lethal scorpion with potentially cytotoxic venom. Various degrees of local and systemic toxicity have been observed after its envenomation ranging from local erythema to disseminated intravascular coagulation, renal failure and severe pulmonary hemorrhage. In this case report, we report on a seven-year-old patient who developed the hemolytic uremic syndrome (HUS) after being stung by the scorpion H. lepturus. This condition is characterized by microangiopathic hemolytic anemia, thrombocytopenia, increased serum levels of lactate dehydrogenase and uremia. We evaluated the causes of HUS and found that the levels of C3, C4, CH50 and H factors were normal, but the activity of Von Willebrand factor cleaving protease was decreased (less than 5% of the normal activity). The patient improved after administering therapy with plasma exchange.


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