Beta thalassemia major: The effect of age on glomerular filtration rate

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ORIGINAL ARTICLE


Year : 2011 \| Volume : 22 \| Issue : 5 \| Page : 963-968

Beta thalassemia major: The effect of age on glomerular filtration rate Majid Malaki¹, Rohangiz Sari Sorkhabi², Maryam Shoaran¹, Bagheri Shafighe³ ¹ Department of Pediatric Nephrology, Tabriz Children's Hospital, Tabriz University of Medical Sciences, Tabriz, Iran ² Department of Oncology and Hematology, Tabriz Children's Hospital, Tabriz University of Medical Sciences, Tabriz, Iran ³ Department of Thalassemia Clinic, Tabriz Children's Hospital, Tabriz University of Medical Sciences, Tabriz, Iran Correspondence Address: Majid Malaki Department of Pediatric Nephrology, Tabriz Children's Hospital, Tabriz University of Medical Sciences, Tabriz Iran PMID: 21912026

Thalassemia is a common hereditary hemoglobinopathy disorder that affects many organs in the body. Estimation of kidney function is important, as it is the vital organ that plays the major role in the elimination of accumulated iron as well as the chelating drugs that have to be used as therapy. Sixty- three patients aged 1-29 years, with a mean ± SD of 14 ± 6.7 years, affected with beta- thalassemia major in Tabriz Children's Hospital were evaluated for their renal function on the basis of their age, serum iron, serum ferritin and serum creatinine levels along with two methods of estimating glomerular filtration rate (GFR); by Schwartz method for those under 18 years old and using Modification of Diet in Renal Disease (MDRD) formula for those who were 18 years and above. Elevation of serum creatinine denoting renal dysfunction was not seen in our patients, but hyperfiltration was a common finding. An increasing GFR was observed, which corresponded to age, but no relationships were seen between serum iron, serum ferritin, regular blood transfusion, chelating therapy to GFR.



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