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Saudi Journal of Kidney Diseases and Transplantation
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CASE REPORT Table of Contents   
Year : 2011  |  Volume : 22  |  Issue : 6  |  Page : 1208-1210
Isolated sarcoid renal granulomatous tubulointerstitial disease


1 Nephrology Unit, Mubarak Al Kabeer Hospital, Ministry of Health, Kuwait
2 Department of Histopathology, Mubarak Al Kabeer Hospital, Ministry of Health, Kuwait
3 Department of Medicine, Mubarak Al Kabeer Hospital, Ministry of Health, Kuwait

Correspondence Address:
Amal Abdel Ghani
Nephrology Department, Mubarak Al Kabeer Hospital, P.O. Box 43787, Code 3205, Hawally
Kuwait
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PMID: 22089784

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A 37-year-old lady presented with hypercalcemia and acute renal impairment. She had no previous medical problems apart from the use of non steroidal anti-inflammatory drugs for nonspecific body pains. Her abdominal ultrasound scan as well as urine studies were nonspecific. Further workup for hypercalcemia (skeletal survey, high resolution computed tomography (CT) of the chest and abdomen, purified protein derivative (PPD) test, serum protein electrophoresis, tumor markers, immunology screening, and Bence Jones proteinuria) was negative. Serum angiotensin converting enzyme was high. Renal biopsy showed extensive lymphocytes and multinucleated giant cells infiltration forming interstitial non necrotizing granulomata. Immune staining as well as staining for acid fast bacilli was negative. The possibility of sarcoid renal granulomata was raised and the patient was started on oral prednisolone with subsequent normalization of renal functions and serum calcium after one month of treatment.


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