Predisposing factors for renal scarring in children with urinary tract infection

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ORIGINAL ARTICLE


Year : 2012 \| Volume : 23 \| Issue : 3 \| Page : 532-537

Predisposing factors for renal scarring in children with urinary tract infection Fatemeh Beiraghdar¹, Yunes Panahi², Behzad Einollahi¹, Yashar Moharamzad¹, Eghlim Nemati¹, Susan Amirsalari³ ¹ Nephrology and Urology Research Center, Baqiyatallah Medical Sciences University, Tehran, Islamic Republic of Iran ² Chemical Injury Research Center, Baqiyatallah Medical Sciences University, Tehran, Islamic Republic of Iran ³ Department of Pediatrics, Baqiyatallah Medical Sciences University, Tehran, Islamic Republic of Iran Correspondence Address: Yunes Panahi Chemical Injury Research Center, Baqiyatallah Medical Sciences University, Vanak, Sq., Molla-Sadra Ave., Tehran Islamic Republic of Iran

This study was undertaken to determine the predisposing factors for renal scarring in children with urinary tract infection. In this prospective cohort study, 176 children with documented urinary tract infection were categorized into four groups: ≤1 year old, 1-2 years old, 2-7 years and 7-14 years old. Ultrasonography and Technetium-99 m-DMSA scan were used to detect the possible abnormalities. Infants under 12 months old presented as the most common group for renal scarring (27 cases, 52.9%), and vesicoureteral reflux (VUR) was diagnosed in 29 cases (56.8%). Fifteen (41.67%) children between the ages of one and two years had renal scar, and VUR was detected in half of the patients. In the third group, 36.3%, and in fourth group, 41.6% of the patients had renal scar. Also, 38.6% in group three and 50% in the final group had VUR. A co-incidental finding that was observed in this study was the high incidence of pseudohypoaldesteronism (PHA) in our patients: in 39.2% of the children in group one, 22.2% in group two and 4% in group three. In group four however, none of the patients had PHA. Risk of scar formation with urinary tract infection (UTI) was higher in the younger age group and in those with recurrent UTIs.



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