Home About us Current issue Back issues Submission Instructions Advertise Contact Login   

Search Article 
  
Advanced search 
 
Saudi Journal of Kidney Diseases and Transplantation
Users online: 448 Home Bookmark this page Print this page Email this page Small font sizeDefault font size Increase font size 
 


 
Table of Contents   
CASE REPORT  
Year : 2012  |  Volume : 23  |  Issue : 3  |  Page : 572-576
Posterior reversible encephalopathy syndrome in a patient with lupus nephritis


1 Department of Medicine, Baylor College of Medicine, Houston, TX, USA
2 Department of Radiology, St. Luke's Hospital, Houston, TX, USA
3 Department of Medicine; Division of Nephrology, Baylor College of Medicine, Houston, TX, USA

Click here for correspondence address and email

Date of Web Publication7-May-2012
 

   Abstract 

Posterior reversible encephalopathy syndrome (PRES) is characterized by acute onset of headache, nausea, focal neurological deficits or seizures along with radiological findings of white matter defects in the parietal and occipital lobes. Causes of PRES include uremia, hypertensive encephalopathy, eclampsia and immunosuppressive medications. Usually, the treat­ment of choice involves correcting the underlying abnormality. We describe an unusual case of recurrent PRES caused by uremia during a lupus flare in a patient with biopsy-proven Class IV Lupus Nephritis (LN) with vasculitis. PRES in systemic lupus erythematosis (SLE) is a rare clin­ical phenomenon and, when reported, it is associated with hypertensive encephalopathy. Our patient did not have hypertensive crisis, but had uremic encephalopathy. The patient's PRES-related symptoms resolved after initiation of hemodialysis. The temporal correlation of the correc­tion of the uremia and the resolution of the symptoms of PRES show the etiology to be uremic encephalopathy, making this the first reported case of uremia-induced PRES in Class IV LN with vasculitis.

How to cite this article:
Kadikoy H, Haque W, Hoang V, Maliakkal J, Nisbet J, Abdellatif A. Posterior reversible encephalopathy syndrome in a patient with lupus nephritis. Saudi J Kidney Dis Transpl 2012;23:572-6

How to cite this URL:
Kadikoy H, Haque W, Hoang V, Maliakkal J, Nisbet J, Abdellatif A. Posterior reversible encephalopathy syndrome in a patient with lupus nephritis. Saudi J Kidney Dis Transpl [serial online] 2012 [cited 2019 Jul 21];23:572-6. Available from: http://www.sjkdt.org/text.asp?2012/23/3/572/95813

   Introduction Top


Posterior reversible encephalopathy syndrome (PRES) is both a clinical and a radiological entity. [1],[2] Clinically, PRES is characterized by headache, vomiting, visual perception abnormalities [3] and seizures. [4],[5] Radiologically, PRES is characterized by abnormalities in the white matter of the parietal and occipital lobes. [6],[7] The findings consistent with PRES are typi­cally recognized in patients with medically diverse conditions including, but not limited to, systemic lupus erythymatosus (SLE), [8] eclam­psia and pre-eclampsia [9] and end-stage renal disease. [10] PRES has been reported as a compli­cation of various therapeutic intervention stra­tegies such as organ transplantation, [11],[12] phar­macological use of cyclosporine and tacrolimus [13],[14] as well as chemotherapy. [15] Neurolo­gical symptoms of patients diagnosed with Lupus Nephritis (LN), include seizures and psychosis. The seizures and psychosis associated with SLE can take place even in the absence of uremia, keto-acidosis and electrolyte imbalance. [16] While the involvement of the central nervous system in SLE has been well docu­mented, there have been only a few cases of LN associated with PRES, and in these cases the PRES was attributed to hypertension from LN. Here, we describe a patient with LN and vasculitis and acute renal failure who presents with recurrent PRES secondary to uremia.


   Case Report Top


A 22-year-old Hispanic woman with a history of SLE presented to the emergency room (ER) with a three-day history of shortness of breath, swelling of the legs and headache. The patient was found to have acute kidney injury and kidney biopsy revealed Class IV LN with vasculitis [Figure 1]. The patient was treated with steroids, cyclophosphomide and adjunct rituximab. On day nine of hospitalization, while the patient's presenting symptoms were impro­ving, the patient had two seizures consisting of loss of consciousness, upper extremity sha­king, drooling, eyes rolling back and postictal confusion. The patient reported headache and dizziness, but denied double vision or confu­sion. The patient never smoked or used alcohol and she had no drug allergies. Family history was significant for a brother with type 1 dia­betes. The patient's vital signs included a blood pressure of 154/97 mmHg, pulse of 81 and temperature of 98.1°F. Neurologic exam showed cognitive slowing and slowed coordination, but normal cranial nerve function, equal and sym­metric deep tendon reflexes and 5/5 strength bilaterally.
Figure 1: Biopsy of the kidney showing glomerular changes consistent with Lupus Nephritis class IV with vasculitis. There is global endocapillary proliferation in the glomerulus (black arrow); a small artery showing mononuclear infiltration in the vessel wall, limited to the intima(straight open arrow); and a small vessel with mononuclear inflammatory cells in the
media and fibrin deposition within the lumen (curved open arrow).


Click here to view


On laboratory evaluation, the patient had serum blood urea nitrogen (BUN) of 90 mg/dL, creatinine of 3.7 mg/dL, white blood cell count of 12.6 g/dL and hemoglobin of 9.2 g/dL. The other laboratory values including sodium, po­tassium, calcium, glucose, liver function tests and coagulation studies were normal. A non-contrast computed tomogoraphy (CT) was done on the day of the seizures, and it showed no acute intracranial pathology. A magnetic resonance imaging (MRI) T2 with fluid-atte­nuated inversion recovery (FLAIR) showed hyperintensity prominently involving the sub­cortical white matter of the bilateral posterior cerebral hemispheres with some additional involvement of the bilateral cerebellar hemis­pheres [Figure 2].
Figure 2: MRI FLAIR image on the day after the seizure episode, which demonstrates bilateral posterior leukoencephalopathy.

Click here to view


The patient was treated with hemodialysis and anti-seizure medication (levetiracetam), after which the patient's clinical condition improved after initiation of hemodialysis, and the seizure episodes resolved. An MRI ten days after initiation of dialysis demonstrated resolution of the initial cerebral lesions [Figure 3]. The patient was discharged 20 days after presentation with a normal neurologic exami­nation. During close observation while the peritoneal dialysis catheter was healing, the patient presented again to the ER with recur­rent seizures two weeks after discharge. The patient's laboratory values showed urea of 85 mg/dL and creatinine of 3.5 mg/dL, white blood cell count of 11.3 g/dL and hemoglobin of 9.1 g/dL. The patient was treated with emer­gent hemodialysis and her clinical condition improved immediately. At this time, peritoneal dialysis (PD) was initiated and the patient was discharged to continue chemotherapy. At one-year follow-up, the patient is seizure-free of anti-seizure medications.
Figure 3: MRI FLAIR image 10 days after dialysis, showing complete resolution of the pathology.

Click here to view



   Discussion Top


PRES was initially described in 1996 as a cli­nical entity consisting of both neurologic and radiological findings. [17] It is characterized by acute onset of headache, altered mental status, visual disturbance and seizures along with ra­diological findings of vasogenic edema, prima­rily in the posterior fossa and parietal and occi­pital lobes of the brain. [4],[18]

PRES can be caused by a variety of clinical entities including uremia, hypertensive encephalopathy, pre-eclampsia/eclampsia, immunosuppressive therapy (primarily cyclosporine and tacrolimus) and connective tissue diseases. [1],[4] From 1988 to 1994, 15 patients were evaluated based on the radiological features of PRES using both CT and MRI. [17] The majority of these patients were either post-transplant pa­tients receiving immunosuppressive therapy or patients with acute hypertensive encephalopathy. Another search from the Medline data­base from 1966 to 2007 revealed 22 patients who were specifically described with rever­sible leukoencephalopathy in the background of SLE. [4] The PRES-associated neurological deficits in the all of these patients resolved either after the withdrawal of immunosuppressive medications or the initiation of antihypertensive therapies. PRES in the background of lupus nephritis is an uncommon phenomenon, and when it does occur, it is usually associated with hypertensive encephalopathy. [4] The pa­tient in our case presented with seizures and acute renal failure due to LN, with BUN and creatinine levels of 90 mg/dL and 3.7 mg/dL, respectively. Interestingly, this patient's blood pressure was not significantly high, but the uremia was most prominent. In this setting, hemodialysis was done to rule out uremia as the etiological factor for the patient's neuro­logical symptoms. Fortunately, her symptoms resolved with dialysis.

While the patient was being closely moni­tored for healing of PD catheter to prevent leak prior to dialysis initiation, she presented to the emergency room with recurrent seizures. All the laboratory values were normal except BUN of 85 mg/dL. This second presentation with elevated urea values similar to the previous one further confirms the association of PRES with uremia.

Although several cases of PRES have been observed and documented, the exact cause of PRES has not been determined. It is possible that multiple pathophysiological processes can generate the clinical and radiological findings consistent with PRES.

The major final common pathway mechanism that explains the radiological findings consis­tent with PRES is vasogenic edema [15] ; how­ever, in a minority of the cases, cytotoxic ede­ma is also observed. The increased prevalence of vasogenic edema over cytotoxic edema in patients with PRES may be explained by the fact that the changes associated with vasogenic edema tend to be reversible. Numerous reports describe the role of hypertensive encephalopathy in the generation of vasogenic edema. [19],[20],[21],[22] When hypertension-induced hyperperfusion of the brain overwhelms the capability of cerebrovascular autoregulation to regulate blood flow, the excess hydrostatic pressure causes increased flow of fluid out of the vasculature into the brain parenchyma. Hypertension-in­duced injury of the endothelial cells lining the capillaries of the cerebrovasculature also causes increased capillary permeability resulting in increased movement of fluid from the vasculature of the brain to the brain parenchyma. [23] Clinically, hypertensive encephalopathy requires that a patient experience sudden increase in blood pressure for a period creating a hyper­tensive emergency. In a study of the clinical characteristics of SLE patients who presented with PRES, [4] 87% of the patients demonstrated a systolic blood pressure of at least 165 mmHg and a diastolic pressure of at least 100 mmHg, unlike the blood pressure in our patient, which was consistently in the 150s/90s. The norma­lization of the blood pressure in these patients resulted in the resolution of the clinical and radiological findings of PRES.

Azotemia is believed to cause vasogenic edema by causing an increase in the permeability of the capillary membrane and cytotoxic edema by direct toxicity to cells in the brain paren­chyma. Azotemia can cause vasogenic edema when the elevated plasma levels of nitroge­nous waste products in uremic encephalopathy alter the permeability of capillary membranes, allowing more fluid to move from the intravascular space into the brain parenchyma. Azotemia can cause cytotoxic edema when some nitrogenous waste products, specifically guanidine compounds, can enter the brain parenchyma and activate neuronal NMDA re­ceptors leading to ultimate excite-toxic cell death. [24] Destruction of neurons leads to the release of intracellular fluid into the extracel­lular space causing cytotoxic edema. Because dialysis in a patient with renal failure decrea­ses the presence of nitrogenous waste products in the plasma, the vasogenic edema due to uremic encephalopathy can be reversed with dialysis alone, as demonstrated in the manage­ment of our patient. Our patient had a BUN level of 85-90 mg/dL during the symptomatic phase of PRES. The clinical and radiological findings of PRES resolved immediately after hemodialysis decreased the BUN level to less than 60 mg/dL. The temporal correlation of the correction of the BUN and the resolution of the symptoms of PRES show the pathophysiological etiology in this patient was uremic encephalopathy, making this the first reported case of uremia-induced PRES in Class IV LN with vasculitides.

The diagnosis of PRES rests upon demonstra­tion of both clinical and radiologic findings consistent with the disorder. FLAIR MRI is the modality of choice in detecting subcortical leukoencephalopathy in the regions that are characteristic of PRES, particularly the poste­rior fossa and the parietal and occipital lobes. The utilization of the diffusion-weighted ima­ging (DWI) MRI technique can be helpful in differentiating between ischemic lesions (cytotoxic edema) and lesions due to PRES (vasogenic edema); ischemic lesions would display hyperintensity on DWI while PRES lesions would display hypointensity. [18] CT study can also be helpful in ruling out acute infarct or hemorrhagic stroke in the same vicinity.

The treatment for PRES depends on the underlying cause; however, antiepileptic drugs should be used to control acute seizures. [4] As was demonstrated in our patient, if uremia is deemed to be significant in the explanation of PRES, then hemodialysis should be carried out to improve the patient's condition. In hypertensive urgency, the treatment of PRES would entail lowering the blood pressure with anti-hypertensive medications. [10] Patients presenting with PRES who are also on immunosuppresive therapy should have their medications temporarily withheld or the dosages decreased until the neurological symptoms of PRES im­prove. The neurological deficits due to PRES itself are only transient so long as the under­lying cause is addressed in a timely manner; therefore, observation of neurological symp­toms such as headache, visual loss, altered mental status and seizures in the setting of uremia should prompt immediate investigation with brain imaging techniques. [14]

 
   References Top

1.Chtioui H, Zimmermann A, Dufour J. Unusual Evo­lution of Posterior Reversible Encephalopathy Syn­drome (PRES) One Year after Liver Transplan­tation. Liver Transplantation 2005; 11:588-90.  Back to cited text no. 1
    
2.Lepoivre T, Treilhaud M, Auffray-Calvier E, Rigal JC, Blanloeil Y. Posterior reversible encephalopathy syndrome: about 2 cases related to the cyclosporine. Ann Fr Anesth Reanim 2003;225:466-9.  Back to cited text no. 2
    
3.Lamy C, Oppenheim C, Meder JF, Mas JL. Neuro-imaging in Posterior Reversible Encephalopathy Syndrome. J Neuroimaging 2004; 14:89-94.  Back to cited text no. 3
    
4.Zhang Y, Liu J, Ding M, et al. Reversible Posterior Encephalopathy Syndrome in Systemic Lupus Erythematosus and Lupus Nephritis. Internal Medicine 2008;47:867-75.  Back to cited text no. 4
    
5.Patel AB, Shaikh S. Posterior Reversible Encephalopathy Syndrome (PRES). Indian Pediatrics 2006; 43:657-8.  Back to cited text no. 5
    
6.Weier K, Fluri F, Kos S, Gass A.Postcontrast Flair MRI demonstrates blood-brain barrier dysfunction in PRES. Neurology 2009;72:760-2.  Back to cited text no. 6
    
7.Casey SO, Sampaio RC, Michel E, Truwit CL. Pos­terior reversible encephalopathy syndrome: utility of fluid-attenuated inversion recovery MR imaging in the detection of cortical and subcortical lesions. AJNR Am J Neuroradiol 2000;21:1199-206.  Back to cited text no. 7
    
8.Baizabal-Carvallo JF, Barragán-Campos HM, Padilla-Aranda HJ, et al. Posterior reversible encephalopathy syndrome as a complication of acute lupus activity. Clin Neurol Neurosurg 2009;111: 359-63.  Back to cited text no. 8
    
9.Servillo G, Striano P, Striano S, et al. Posterior reversible encephalopathy syndrome (PRES) in cri­tically ill obstetric patients. Intensive Care Med 2003;29:2323-6.  Back to cited text no. 9
    
10.Ergün T, Lakadamyali H, Yilmaz A. Recurrent posterior reversible encephalopathy syndrome in a hypertensive patient with end-stage renal disease. Diagn Interv Radiol 2008;14:182-5.  Back to cited text no. 10
    
11.Lanzino G, Cloft H, Hemstreet MK, West K, Alsotn S, Ishitani M. Reversible posterior leukoencephalopathy following organ trans-plantation: Description of two cases. Clinical Neurology and Neurosurgery 1997;99:222-6.  Back to cited text no. 11
    
12.Bartynski WS, Tan HP, Boardman JF, Shapiro R, Marsh JW. Posterior reversible encephalopathy syndrome after solid organ transplan-tation. AJNR Am J Neuroradiol 2008;29:924-30.  Back to cited text no. 12
    
13.Yamamoto A, Hayakawa K, Houjyou M. CT and MRI findings of cyclosporine-related encephalopathy and hypertensive encephalopathy. Pediatr Radiol 2002;32:340-3.  Back to cited text no. 13
    
14.Reinohs M, Straube T, Baum P, Berrouschot J, Wagner A. Recurrent reversible cerebral edema after long term immunosuppression with tacro-limus. J Neurol 2002;249:780-1.  Back to cited text no. 14
    
15.Bhatt A, Farooq MU, Majid A, Kassab M. Chemo­therapy-related posterior reversible leukoencephalopathy syndrome. Nat Clin Pract Neurol 2009;5:163-9.  Back to cited text no. 15
    
16.Kumar V, Abbas A, Fausto N. Robbins and Cotran Pathologic Basis of Disease 7 th ed, New York, NY: Elsevier. 2004:228.  Back to cited text no. 16
    
17.Hinchey J, Chaves C, Appignani B, et al. A rever­sible posterior leukoencephalopathy syndrome. N Engl J Med 1996;334:494-500.  Back to cited text no. 17
    
18.Doelken M, Lanz S, Rennert J, Alibek S, Richter G, Doerfler A. Differentiation of cytotoxic and vasogenic edema in a patient with reversible posterior leukoencephalopathy syndrome using diffusion-weighted MRI. Diagn Interv Radiol 2007;13:125-8.  Back to cited text no. 18
    
19.Thaipisuttikul I, Phanthumchinda K. Recurrent re­versible posterior leukoencephalopathy in a patient with systemic lupus erythematosus. J Neurol 2005; 252:230-23.  Back to cited text no. 19
    
20.Min L, Zwerling J, Ocava LC, Chen IH, Putterman C. Reversible posterior leukoencephalopathy in connective tissue diseases. Semin Arthirtis Rheum 2006;35:388-95.  Back to cited text no. 20
    
21.Magnano MD, Bush TM, Herrera I, Altman RD. Reversible posterior leukoencephalopathy in pa­tients with systemic lupus erythematosis. Semin Arthritis Rheum 2006;35:396-402.  Back to cited text no. 21
    
22.Backshi R, Shaikh ZA, Bates VE, Kinkel PR. Thrombotic thrombocytopenic purpura: brain CT and MRI findings in 12 patients. Neurology 1999; 52:1285-8.  Back to cited text no. 22
    
23.Brouns R, De Deyn PP. Neurological complications in renal failure: a review. Clin Neurol Neurosurg 2004;107:1-16.  Back to cited text no. 23
    
24.De Deyn PP, D'Hooge R, Van Bogaert PP, Marescau B. Endogenous guanidino compounds as uremic neurotoxins. Kidney Int Suppl 2001;78:77-83.  Back to cited text no. 24
    

Top
Correspondence Address:
Abdul Abdellatif
Assistant Professor of Medicine, Department of Medicine, Division of Nephrology, Baylor College of Medicine, One Baylor Plaza, BCM 620, Houston, TX 77030
USA
Login to access the Email id


Rights and Permissions


    Figures

  [Figure 1], [Figure 2], [Figure 3]

This article has been cited by
1 Posterior reversible encephalopathy syndrome [SĂ­ndrome de encefalopatĂ­a reversible posterior]
Carrillo-Esper, R. and EchevarrĂ­a-Keel, J. and De Los RĂ­os-Torres, A. and Reyes-Mendoza, L.E.
Medicina Interna de Mexico. 2013; 29(3): 299-306
[Pubmed]
2 Posterior reversible encephalopathy syndrome in systemic lupus erythematosus: Pooled analysis of the literature reviews and report of six new cases
Shaharir, S.S. and Remli, R. and Marwan, A.A. and Said, M.S.M. and Kong, N.C.T.
Lupus. 2013; 22(5): 492-496
[Pubmed]
3 Headache and vasculitis topical collection on uncommon headache syndromes
Lopez, J.I. and Holdridge, A. and Chalela, J.
Current Pain and Headache Reports. 2013; 17(3)
[Pubmed]



 

Top
   
 
 
    Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
    Email Alert *
    Add to My List *
* Registration required (free)  
 


 
    Abstract
   Introduction
   Case Report
   Discussion
    References
    Article Figures
 

 Article Access Statistics
    Viewed3752    
    Printed83    
    Emailed0    
    PDF Downloaded863    
    Comments [Add]    
    Cited by others 3    

Recommend this journal