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Saudi Journal of Kidney Diseases and Transplantation
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Year : 2013  |  Volume : 24  |  Issue : 2  |  Page : 230-234
Autosomal dominant polycystic kidney disease: New insights into treatment


Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO, USA; Laboratory of Kidney Pathology (LR00SP01-Pr Ben Maiz Hedi) Charles Nicolle Hospital, Faculty of Medicine, University of Tunis El Manar, Tunis, Tunisia

Correspondence Address:
Imed Helal
University of Colorado Denver, Division of Renal Diseases and Hypertension, Box C-281. 1270 East 19th. RC2 7th floor Room 7001, Aurora, Colorado 80045, USA

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DOI: 10.4103/1319-2442.109561

PMID: 23538343

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Autosomal dominant polycystic kidney disease (ADPKD) is the world's most common inherited kidney disease. An increasing number of animal and human studies have enhanced our understanding of the molecular and cellular pathology of ADPKD. New treatment options are being tested in clinical trials in spite of the failure of mammalian target of rapamycin inhibitor therapy. The main and most effective therapy remains control of hypertension by renin-angiotensin-aldosterone system (RAAS) blockade. This review focuses only on promising therapies, including dual inhibition of RAAS, vasopressin receptor antagonists, increased fluid intake, and blockade of certain receptors of cyclic adenosine monophosphate. Also, the paper reviews what these advances mean to patients and clinicians and elaborates on how these changes can be immediately applied to clinical practice. There is an urgent need for discovery of new therapies targeted toward ADPKD in comparison with therapeutic progress of all other renal diseases.


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