Home About us Current issue Back issues Submission Instructions Advertise Contact Login   

Search Article 
  
Advanced search 
 
Saudi Journal of Kidney Diseases and Transplantation
Users online: 2006 Home Bookmark this page Print this page Email this page Small font sizeDefault font size Increase font size 


 
CASE REPORT Table of Contents   
Year : 2013  |  Volume : 24  |  Issue : 4  |  Page : 768-772
Rhino-orbitocerebral mucormycosis in a patient with idiopathic crescentic glomerulonephritis


1 Parsa Hospital, Tehran, Iran
2 Department of Nephrology, Shahed University, Mustafa Khomeini Hospital, Tehran, Iran
3 Department of Neurology, Shahed University, Mustafa Khomeini Hospital, Tehran, Iran

Correspondence Address:
Suzan Sanavi
Parsa Hospital, Tehran
Iran
Login to access the Email id


DOI: 10.4103/1319-2442.113878

PMID: 23816728

Rights and Permissions

Mucormycosis, caused by mucorales, is an acute, rapidly progressive infection associated with high mortality. Rhino-orbitocerebral infection is the most common variant and is generally seen in association with immune deficiency syndromes. Prompt medical treatment of this infection and debridement decreases the mortality rate. We describe a 47-year-old man with crescentic glomerulonephritis on maintenance prednisolone therapy. He had earlier received steroid and cyclophosphamide pulse therapies. Renal functions improved following immunosuppressive treatment. In the third month of maintenance therapy, he presented to us with left-sided facial swelling and bloody nasal discharge. He had high blood sugar and acidic blood pH (ketoacidosis), probably due to steroid therapy. Magnetic resonance imaging of the head and sinuses showed inflammation and mass in the ethmoid sinus and nose with partial septal destruction, proptosis, global destruction of the left eye, brain infarction and carotid artery obliteration. Endoscopic biopsy of the sinuses revealed severe tissue necrosis. Samples of nasal discharge and biopsy tissue showed aseptate hyphae on light microscopy and culture, compatible with Rhizopus. The patient was treated with amphotericin B and multiple wound debridements along with ethmoidectomy and enucleation of the left eye. He was discharged in good general condition but with mild right hemiparesis. On follow-up examination at one year, there were no signs of fungal infection or renal dysfunction.


[FULL TEXT] [PDF]*
Print this article  Email this article
    

  Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
   Citation Manager
  Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1359    
    Printed33    
    Emailed0    
    PDF Downloaded282    
    Comments [Add]    

Recommend this journal