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Saudi Journal of Kidney Diseases and Transplantation
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ORIGINAL ARTICLE Table of Contents   
Year : 2013  |  Volume : 24  |  Issue : 6  |  Page : 1165-1169
Predictors of early post-operative hypocalcemia after parathyroidectomy for secondary hyperparathyroidism


1 Department of Nephrology, Fattouma Bourguiba Hospital; Department of Epidemiology, University Hospital of Monastir University Faculty of Medicine, Monastir, Tunisia
2 Department of Preventive Medicine; Department of Epidemiology, University Hospital of Monastir University Faculty of Medicine, Monastir, Tunisia

Correspondence Address:
M Hamouda
Department of Nephrology, Fattouma Bourguiba Hospital, Monastir, 5000
Tunisia
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DOI: 10.4103/1319-2442.121273

PMID: 24231478

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We sought to identify predictors of development of early post-operative hypocalcemia after parathyroidectomy for secondary hyperparathyroidism. The patients were divided into two groups according to their serum calcium (Ca) levels within 24 hours of undergoing para-thyroidectomy: the hypocalcemia group (22 patients) with post-operative serum Ca levels of 2 mmol/L or less, and the normocalcemia group (48 patients), with post-operative serum Ca levels higher than 2 mmol/L. By using multivariate stepwise logistic regression analysis, high pre-operative serum Ca level had the strongest predictive value of development of early hypocalcemia with an adjusted odds ratio (aOR) of 3.01, followed by hypo-albuminemia (aOR = 2.72), younger age (aOR = 2.56), and high pre-operative alkaline phosphatase (ALP) levels (aOR = 2.28). We conclude that among patients with secondary hyperparathyroidism, age, levels of pre-operative serum Ca, ALP and albumin correlate positively with the development of early post-operative hypocalcemia. Patients with one of these factors should be monitored more closely in the early post-parathyroidectomy period.


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