Home About us Current issue Back issues Submission Instructions Advertise Contact Login   

Search Article 
  
Advanced search 
 
Saudi Journal of Kidney Diseases and Transplantation
Users online: 958 Home Bookmark this page Print this page Email this page Small font sizeDefault font size Increase font size 
 


 
Table of Contents   
LETTER TO THE EDITOR  
Year : 2013  |  Volume : 24  |  Issue : 6  |  Page : 1248-1249
Cytomegalovirus infection following renal transplantation: An analysis of 21 cases in an endemic area


1 Sanitation 1 Medical Academic Center, Bangkhae, Bangkok, Thailand
2 Wiwanitkit House, Bangkhae, Bangkok, Thailand

Click here for correspondence address and email

Date of Web Publication13-Nov-2013
 

How to cite this article:
Joob B, Wiwanitkit V. Cytomegalovirus infection following renal transplantation: An analysis of 21 cases in an endemic area. Saudi J Kidney Dis Transpl 2013;24:1248-9

How to cite this URL:
Joob B, Wiwanitkit V. Cytomegalovirus infection following renal transplantation: An analysis of 21 cases in an endemic area. Saudi J Kidney Dis Transpl [serial online] 2013 [cited 2019 Aug 25];24:1248-9. Available from: http://www.sjkdt.org/text.asp?2013/24/6/1248/121290
To the Editor,

An important problem in renal transplant recipients is the development of infection. Infections in this group of patients can be severe and fatal. Appropriate screening of the donor and recipient, drug prophylaxis, and good infection control seem to be the key factors in preventive management. Of the several infections that can occur in renal transplant recipients, cytomegalovirus (CMV) infection is important. [1] We herein briefly summarize and discuss the case reports published on CMV infection in renal transplant recipients in Thailand, a country endemic for this infection. We performed a literature search using standard database (PubMed) and local reference database (Thai Index Medicus), with the key words "transplantation," "kidney," and "cytomegalovirus." The derived publications with the details on the renal transplant recipients were used for summative analysis. Based on the search, three publications were analyzed. [2],[3],[4] These publications covered 21 indexed cases (11 males and 10 females, aged between 41 and 56 years). Pre-transplant serological data were available in 20 cases. The donor serology revealed that all 20 cases were CMV sero-positive (100%) and the recipient serology revealed CMV seropositivity in 18 cases (90%). All the study patients received the immunosuppressive drug cyclosporine. The clinical presentation in all cases was fever with urinary tract infection; one case had bloody diarrhea in addition. The incubation period of the infection was between seven weeks and seven months. All the patients were treated with the drug ganciclovir. Following treatment, complete recovery was seen in 17 cases and allograft rejection and death occurred in one case each.

A recent report has confirmed that the problem of latent CMV infection among renal transplant recipients is very important and could result in graft rejection and death. [5] It has been proved that the infection is an independent risk factor for graft rejection. [5] Based on this work, it could be seen that the seropositivity among the donors was 100%, indicating the endemicity of the disease. Hence, proper donor selection might be the clue for prevention of CMV infection. Focusing on the recipient, pre-transplant screening will be helpful in identification of the sero-negative cases who could be the target group for close monitoring and use of drug prophylaxis.

 
   References Top

1.Rostaing L, Wéclawiak H, Mengelle C, Kamar N. Viral infections after kidney transplantation. Minerva Urol Nefrol 2011;63:59-71.  Back to cited text no. 1
    
2.Sookpranee M, Premyothin P, Jarusiripipat C, Supasiti T. Persistent fever after urinary tract infection in a renal recipient. J Infect Dis Antimicrob Agents 1994;1:133-6.  Back to cited text no. 2
    
3.Nayudhaya DP, Praditpornsilpa K, Tewthanom K. The Incidence of cytomegalovirus infection in renal transplant patients: Single center study. Thai J Pharm Sci 2003;27 Suppl:42.  Back to cited text no. 3
    
4.Nayudhaya DP, Praditpornsilpa K, Tewthanom K. The Incidence of cytomegalovirus infection in renal transplant patients: Single center study. Chula Med J 2004;48:343-55.   Back to cited text no. 4
    
5.van Ree RM, de Vries AP, Zelle DM, et al. Latent cytomegalovirus infection is an independent risk factor for late graft failure in renal transplant recipients. Med Sci Monit 2011; 17:CR609-17.  Back to cited text no. 5
    

Top
Correspondence Address:
Beuy Joob
Sanitation 1 Medical Academic Center, Bangkhae, Bangkok
Thailand
Login to access the Email id


DOI: 10.4103/1319-2442.121290

PMID: 24231494

Rights and Permissions




 

Top
   
 
 
    Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
    Email Alert *
    Add to My List *
* Registration required (free)  
 


 
    References
 

 Article Access Statistics
    Viewed825    
    Printed17    
    Emailed0    
    PDF Downloaded238    
    Comments [Add]    

Recommend this journal