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Saudi Journal of Kidney Diseases and Transplantation
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Table of Contents   
RENAL DATA FROM THE ARAB WORLD  
Year : 2014  |  Volume : 25  |  Issue : 1  |  Page : 192-195
End-stage renal disease in Tabuk Area, Saudi Arabia: An epidemiological study


1 Department of Internal Medicine, School of Medicine, University of Tabuk, Tabuk, Saudi Arabia
2 Department of Community Medicine, School of Medicine, University of Tabuk, Tabuk, Saudi Arabia
3 Department of Physiology, School of Medicine, University of Tabuk, Tabuk, Saudi Arabia

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Date of Web Publication7-Jan-2014
 

   Abstract 

The purpose of this study was to determine the prevalence, etiology and risk fac­tors of treated end-stage renal disease (ESRD) in the region of Tabuk, Saudi Arabia. We studied 460 renal replacement therapy patients through a review of medical records and patient interviews and obtained patient demographics, family history, risk factors for ESRD, environmental exposure to toxins, work conditions, social history and causes of death. The estimated prevalence of treated ESRD was 460 per million populations (PMP); 350 (76%) were treated by hemodialysis, 30 (7%) by peritoneal dialysis and 80 (17%) by kidney transplantation. The mean age was 48 ± 17 years, body mass index was 25 ± 2 kg/m 2 and the male vs. female ratio was 64% vs. 36%. Most patients (55%) were living in rural areas. Etiology of the ESRD was unknown in 33%, hypertension in 24%, chronic glomerulonephritis in 8%, obstructive uropathy in 3.5%, analgesic nephropathy in 5%, Bilhaziasis in 0.5%, chronic pyelonephritis in 2% and diabetic nephropathy in 18%. Other causes such as gouty nephropathy, collagen diseases, toxemia of pregnancy and lupus nephritis constituted 6% of the cases. We conclude that the epidemiology of the treated ESRD in Tabuk area is similar to that in Egypt, but very different from that in the United States.

How to cite this article:
El Minshawy O, Ghabrah T, El Bassuoni E. End-stage renal disease in Tabuk Area, Saudi Arabia: An epidemiological study. Saudi J Kidney Dis Transpl 2014;25:192-5

How to cite this URL:
El Minshawy O, Ghabrah T, El Bassuoni E. End-stage renal disease in Tabuk Area, Saudi Arabia: An epidemiological study. Saudi J Kidney Dis Transpl [serial online] 2014 [cited 2019 Aug 17];25:192-5. Available from: http://www.sjkdt.org/text.asp?2014/25/1/192/124574

Dr. Osama El Minshawy and Dr. Eman El Bassuoni are both on sabbatical leave from El-Minia University School of Medicine, Egypt.


   Introduction Top


The increasing global prevalence of treated end-stage renal disease (ESRD) over the years indicates a general increase in the number of incident patients with kidney failure as well as a gradual improvement in the access to treatment. [1],[2],[3],[4],[5],[6],[7],[8],[9]

In 2007, more than 1.6 million patients were undergoing dialysis treatment worldwide, and another half a million patients were living with a functioning kidney allograft. However, access to treatment is still limited in many countries. [1]

The Kingdom of Saudi Arabia (KSA) is a country with marked rise in prevalence and incidence of ESRD; this rise exceeds those reported from many countries due to enormous and rapid changes in lifestyle, high population growth, fast increase in life expectancy and massive urbanization over the last three decades. [10] The epidemiology of ESRD in Tabuk area has not been extensively examined.

The aim of this study is to describe the ESRD population in the area of Tabuk and to com­pare the epidemiology of ESRD in Tabuk area with that elsewhere.


   Materials and Methods Top


Tabuk region is located along the north-west coast of KSA; it has an area of 108,000 km² and comprises five governorates including 170 villages. In the area of Tabuk, there are seven dialysis centers with variable capacities; six are affiliated with the Ministry of Health and one is in the Prince Sultan Kidney Center. The population of Tabuk is 691,517 (census 2004) and in 2012 it is estimated to be approximately one million persons. In 2012, we conducted a cross-sectional study of all treated ESRD patients undergoing renal replacement therapy (RRT) in the area of Tabuk, Saudi Arabia. Medical records and patient interviews were the primary source of demographic and clin­ical information on the patients.


   Statistical Analysis Top


Analysis of the demographics and clinical characteristics of the dialysis population was restricted to patients who were maintained on hemodialysis (HD) modality for more than five consecutive HD sessions. Statistical ana­lyses were conducted using SPSS software for windows (SPSS-X).


   Results Top


In 2012, a total of 460 patients were on RRT in the area of Tabuk. All were eligible for in­clusion in this study. The prevalence of trea­ted ESRD was 460 PMP. RRT modality was HD in 350 (76%), peritoneal dialysis in 30 (7%) and renal transplantation in 80 (17%) patients.

Prevalent RRT patients had a mean age of was 48 ± 17 years, median 50 years, range (20-93 years). There were nearly twice the number of males to females (64% vs 36%), and the patients were more likely to live in rural vs urban areas (55% and 45%, respec­tively). Renal biopsy was performed in 56 patients (12%) at some time during the course of their sickness. The etiology of treated ESRD was unknown in 33%, hypertension in 24%, chronic glomerulonephritis (GN) in 8%, obstructive uropathy in 3.5%, analgesic nephropathy in 5%, bilhaziasis in 0.5%, chronic pyelonephritis in 2% and diabetic nephropathy (DN) in 18%. Other causes such as gouty nephropathy, collagen diseases, toxemia of pregnancy and lupus nephritis constituted 6% of the cases. [Table 1] shows the primary etio­logy of ESRD among the male and female patients in Tabuk area.
Table 1: Comparison between males and females regarding the etiology of the ESRD.

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[Figure 1] shows the comparison of the diffe­rent etiologies between rural and urban areas in the area of Tabuk. The prevalence of hyper­tension was higher in the urban (16%) than in the rural areas (8%), and analgesic nephropathy was more prevalent in the urban (3%) than in the rural areas (2%). ESRD due to dia­betic nephropathy was significantly higher in the urban (12%) than in the rural areas (6%).
Figure 1: Different etiology between rural and urban areas in Tabuk area.

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Only 25% of the prevalent HD patients had a documented measurement of urea reduction ratio (URR), and only 65% achieved a URR ≥65%. The number of ESRD patients with a functioning kidney graft in 2012 was 80 (17%) patients.


   Discussion Top


The results of our study showed that the pre­valence of treated ESRD in males was almost twice that of females (64% vs 36%). This male predominance among the ESRD population, almost a global phenomenon, is poorly ex­plained, with males constituting 56% in the US, [11] 60% in the UK [12] and 54.5% in the KSA. [10]

Etiology of treated ESRD was unknown in 33% of the patients in the area of Tabuk in 2012. In Sudan, more than 40% of the sur­veyed patients had no identified cause for their renal impairment [9] and in El-Minia Governorate, Egypt, 27% of the patients with treated ESRD had unknown etiology, [13] while the unknown etiology of ESRD in the US is only 3.9%. [11] This difference may be attributed to environmental factors as described previously. [13]

In the current study, hypertension was res­ponsible for about 24% of the causes of treated ESRD in the area of Tabuk. In Sudan, hypertension was responsible for about 26% of the causes of treated ESRD. [9] Similarly, hyperten­sion was the cause of treated ESRD in 28% of ESRD cases in the US. [11] In Iran, the most common cause of treated ESRD among HD patients was hypertension (30.5%), [14] but this is likely an overestimate as the diagnosis of hypertensive nephrosclerosis is difficult to ascertain even in patients with long-standing hypertension. Such patients may have had se­condary hypertension due to undiagnosed kid­ney disease.

Hypertension was reported as a cause of kid­ney failure in 21% of patients on RRT in the South African registry [15] and 20% of the causes of treated ESRD in El-Minia Governorate, Egypt. [5] A similarly wide variation is noted in the reported rates of hypertension as the pri­mary renal diagnosis of ESRD patients in the US and UK (28% and 5.8%, respectively). [11],[12],[16] The variation in the reported rates of hyper­tensive nephrosclerosis likely results from the different definitions of these conditions rather than a true variation of prevalence.

In Sudan, GN was the reported cause of trea­ted ESRD in 5.5% of the patients, [9] 3% in the US [11] and 11% in El-Minia Governorate, Egypt, [5] compared with 8% in our study.

In our study, schistosomiasis (bilharzia) was responsible for about 0.5% of the etiology of treated ESRD in the area of Tabuk. In Egypt, schistosomiasis was responsible for 1.5-6.6% of the treated ESRD. [17]

In the current study, 10% of our patients reported a family history of renal dysfunction, 19% of treated ESRD patients in Sudan and 20% of the patients in the US. [18]

DN as a cause of treated ESRD in the area of Tabuk constituted 8% of causes of treated ESRD in 2009, and increased to 18% accor­ding to the results of the current study. The prevalence of DN among treated ESRD pa­tients was 16% in Egypt in 2008, [19] 48% in Qatar [20] and 38% in the US. [11]

We conclude that our study found a similar epidemiology of treated ESRD in the area of Tabuk as in Egypt, but this was very different from the epidemiology of ESRD in the US.

Conflict of interest: None declared

 
   References Top

1.Fresenius Medical Care. ESRD patients in 2007: A global perspective. Fresenius Medical Deutschland GmbH; 2008.  Back to cited text no. 1
    
2.Olivers MB, Romao JE Jr, Zatz R. End stage renal disease in Brazil: Epidemiology, preven­tion and treatment. Kidney Int Suppl 2005; 97: S82-6.  Back to cited text no. 2
    
3.Al-Rohani M. Renal failure in Yemen. Trans­plant Proc 2004;36:1777-9.  Back to cited text no. 3
    
4.Schon S, Ekberg H, Wikstorm B, Oden A, Ahlmen J. Renal Replacement therapy in Sweden. Scand J Urol Nephrol 2004;38:332-9.  Back to cited text no. 4
    
5.El-Minshawy O. End-stage renal disease in the El-Minia Governorate, Upper Egypt: An Epidemiological Study. Saudi J Kidney Dis Transpl 2011;22:1048-54.  Back to cited text no. 5
    
6.Pérez-Oliva JF. Current status of renal replace­ment therapy in Cuba 2006. Ethn Dis 2009;19 (1 Suppl 1):S1-10-2.  Back to cited text no. 6
    
7.Couchoud C, Lassalle M, Stengel B, Jacquelinet C. Renal Epidemiology and Information Network: 2007 annual report (Abstract) Nephrol Ther 2009: 5 Suppl 1:S3-1.  Back to cited text no. 7
    
8.Boddana P, Caskey F, Casula A, Ansell D. UK Renal Registry 11th Annual Report (December 2008): Chapter 14 UK Renal Registry and inter­national comparisons. Nephron Clin Pract 2009; 111 Suppl 1:269-76.  Back to cited text no. 8
    
9.El-Amin A, Obeid W, Abu-Aisha H. Renal Replacement Therapy in Sudan, 2009. Arab J Nephrol Transpl 2010;3:31-6.  Back to cited text no. 9
    
10.Al-Sayyari AA, Shaheen FA. End Stage Chronic Kidney disease. A rapidly changing scene. Saudi Med J 2011;32:339-46.  Back to cited text no. 10
[PUBMED]    
11.United States Renal Data System, 2012. Annual Data Report: Atlas of End-Stage Renal Disease in the United States. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases division of kidney, urologic, & hematologic diseases.  Back to cited text no. 11
    
12.UK Renal Registry. The 12th annual report [Internet]. Bristol: UK renal Registry; 2009. p. 351. Available from: http://www.renalreg.com/ Report-Area/report/ Renal 09_web.pdf [Last cited on 2010 Mar 20].  Back to cited text no. 12
    
13.Kamel EG, El-Minshawy O. Environmental Factors Incriminated in the Development of End Stage Renal Disease in El-Minia Governorate, Upper Egypt. Int J Nephrol Urol 2010;2:431-7.  Back to cited text no. 13
    
14.Malekmakan L, Haghpanah S, Pakfetrat M, Malekmakan A, Khajehdehi P. Causes of chronic renal failure among Iranian hemodialysis pa­tients. Saudi J Kidney Dis Transpl 2009;20:501-4.  Back to cited text no. 14
[PUBMED]  Medknow Journal  
15.Naicker S. End-stage renal disease in sub-Saharan Africa. Ethn Dis 2009;19(1 Suppl 1):S1-13-5.  Back to cited text no. 15
    
16.Frassinetti FP, Ellis PA, Roderick PJ, Cirns HS, Hicks JA, Cameron JS. Causes of end stage renal failure in black patients. Am J Kidney Dis 2000;36:301-9.  Back to cited text no. 16
    
17.Afifi A, Karim MA. Renal replacement therapy in Egypt; The first annual report of The Egyptian Society of Nephrology, 1996. East Mediterr Health J 1999;5:1023-9.  Back to cited text no. 17
    
18.Freedman BI, Soucie JM, McClellan WM. Family history of end stage renal disease among incident dialysis patients. J Am Soc Nephrol 1997;8:1942-5.  Back to cited text no. 18
    
19.El-Minshawy O, Kamel EG. Diabetics on hemodialysis in El-Minia governorate, Upper Egypt five year study. Int J Urol Nephrol 2011;43:507-12.  Back to cited text no. 19
    
20.Shigidi MM, Ramachandiran G, Rashed AH, Fituri OM. Demographic data and hemodialysis population dynamics in Qatar: A five year survey. Saudi J Kidney Dis Transpl 2009;20:493-500.  Back to cited text no. 20
[PUBMED]  Medknow Journal  

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Correspondence Address:
Osama El Minshawy
Department of Internal Medicine, School of Medicine, University of Tabuk, Tabuk 71421
Saudi Arabia
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DOI: 10.4103/1319-2442.124574

PMID: 24434411

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