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Saudi Journal of Kidney Diseases and Transplantation
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CASE REPORT Table of Contents   
Year : 2014  |  Volume : 25  |  Issue : 2  |  Page : 390-393
Piperazine side-effects in a patient with pre-existing renal insufficiency

Pediatric Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Correspondence Address:
Majid Malaki
Department of Pediatric Nephrology, Pediatric Health Research Center, Post Code 5136735886, Tabriz
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DOI: 10.4103/1319-2442.128573

PMID: 24626010

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Piperazine as an antihelminth has many adverse effects, especially on patients with renal insufficiency. We report the use of piperazine in a girl with a moderately severe kidney disease due to Biedl Bardet syndrome. She developed coma and acute kidney injury due to acute interstitial nephritis (AIN), anemia and thrombocytopenia. The presence of fever, proteinuria, acidosis, anemia, sterile pyuria and non-oliguric renal failure strongly suggested AIN. Her problems abated mostly by discontinuing of piperazine and supportive therapy, except anemia and thrombocytopenia.

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