Home About us Current issue Back issues Submission Instructions Advertise Contact Login   

Search Article 
  
Advanced search 
 
Saudi Journal of Kidney Diseases and Transplantation
Users online: 6034 Home Bookmark this page Print this page Email this page Small font sizeDefault font size Increase font size 

RENAL DATA FROM ASIA - AFRICA Table of Contents   
Year : 2014  |  Volume : 25  |  Issue : 3  |  Page : 689-696
Clinicopathologic spectrum of crescentic glomerulonephritis: A hospital-based study


1 Department of Nephrology, Dialysis and Transplant Unit, SS Hospital, Institute of Medical Sciences, Varanasi, Uttar Pradesh, India
2 Department of Nephrology, Institute of Nephrology, S.S. Hospital, Banaras Hindu University, Varanasi, Uttar Pradesh, India
3 Department of Immunopathology, UGC Advanced Immunodiagnostic, Training and Research Center; Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India

Correspondence Address:
Dr. Tauhidul Alam Choudhury
Department of Nephrology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP
India
Login to access the Email id


DOI: 10.4103/1319-2442.132241

PMID: 24821180

Rights and Permissions

Recent data regarding the clinical and histopathologic spectrum of crescentic glomerulonephritis (CSGN) among the Indian adult population is unknown. Our aim is to study the clinicopathological features and outcome of CSGN. It is a retrospective observational study from a tertiary care hospital in India over 3.5 years. Biopsy-proven cases of CSGN (i.e., >50% crescents in glomeruli) were included in the study. Cases with insufficient data were excluded. There were 34 cases of CSGN, accounting for an incidence of 5.5% among kidney biopsies. The mean age was 32.2 ± 16.09 years, with male to female ratio of 12:22. Clinical presentations of CSGN include rapidly progressive glomerulonephritis in 23 (67.7%), chronic renal failure (CRF) in seven (20.5%), nephrotic syndrome in two (5.8%) and acute nephritic syndrome in two (5.8%) patients. The immunological profile of CSGN showed MPO-ANCA in nine (26.4%), PR3-ANCA in one (2.9%), both PR3 and MPO-ANCA in one (2.9%), anti-GBM antibody in five (14.7%) and lupus nephritis in six (17.6%) patients. All the three antibodies were present in one patient. The percentage of glomeruli showing crescents were 100% in nine (26.4%) and ≥80% in seven (20.5%) patients. Type of crescents seen were cellular in 11 (32.3%) and fibrocellular in 22 (64.7%) patients and fibrous in one (2.9%) patient. Interstitial fibrosis was found in seven (20.5%) patients. Dialysis dependency was seen in 11 (32.3%) patients. After 3 months of follow-up, mortality was seen in three (8.8%), remission in eight (23.5%), CRF in 15 (44.1%) and ESRD in five (14.7%) patients. CSGN carries a poor prognosis. The disorder may have an insidious onset and a slowly progressive course. ANCA, anti-GBM-antibody and anti-dsDNA can coexist in CSGN.


[FULL TEXT] [PDF]*
Print this article  Email this article
    

  Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
   Citation Manager
  Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed4190    
    Printed36    
    Emailed1    
    PDF Downloaded796    
    Comments [Add]    

Recommend this journal