Home About us Current issue Back issues Submission Instructions Advertise Contact Login   

Search Article 
  
Advanced search 
 
Saudi Journal of Kidney Diseases and Transplantation
Users online: 2215 Home Bookmark this page Print this page Email this page Small font sizeDefault font size Increase font size 

BRIEF COMMUNICATION Table of Contents   
Year : 2014  |  Volume : 25  |  Issue : 5  |  Page : 1026-1029
Angiogenic activity in the sera of patients with post-kidney transplant erythrocytosis


1 Nuclear Medicine Department, Pasteur Institute of Tunis, Tunis, Tunisia
2 Nephrology Department, Hedi Chaker Hospital, Sfax, Tunisia
3 National Transfusion Blood Center, Tunis, Tunisia
4 Nephrology Department, Fattouma Bourguiba Hospital, Monastir, Tunisia

Correspondence Address:
Dr. Chokri Maktouf
Nuclear Medicine Department, Pasteur Institute of Tunis, Tunis
Tunisia
Login to access the Email id


DOI: 10.4103/1319-2442.139905

PMID: 25193901

Rights and Permissions

Post-kidney transplant erythrocytosis (PTE) is one of the hematological complications in the renal transplant patients. While its pathogenesis still remains to be elucidated completely, a number of therapies are available for the management of PTE. The aim of this prospective study was to investigate whether angiogenesis may be involved in the pathogenesis of post-transplant erythrocytosis by comparing its level with those of different classes of erythrocytosis [polycythemia vera (PV), idiopathic erythrocytosis and secondary erythrocytosis]. The angiogenic activity was evaluated by the assessment of the serum vascular endothelial growth factor (VEGF) levels, as one of circulating angiogenic factor, using a standardized enzyme-linked immunosorbent assay commercial kit in 13 PTE (2 F/11 M), in 75 untreated erythrocytosis non-transplant patients and in 21 healthy subjects controls. The results indicated that VEGF was overproduced in advanced and untreated PV patients and to a lesser degree in idiopathic erythrocytosis thus confirming an increased angiogenic activity. However, there is no evidence of increased angiogenesis in PTE and in secondary erythrocytosis. The absence of angiogenesis in PTE and its presence in PV is another argument that the pathogenesis of these two entities is different.


[FULL TEXT] [PDF]*
Print this article  Email this article
    

  Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
   Citation Manager
  Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1185    
    Printed28    
    Emailed0    
    PDF Downloaded251    
    Comments [Add]    

Recommend this journal