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Saudi Journal of Kidney Diseases and Transplantation
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ORIGINAL ARTICLE Table of Contents   
Year : 2015  |  Volume : 26  |  Issue : 2  |  Page : 293-296
Comparison of measured glomerular filtration rates with isotope infusion and with the modification of diet in renal disease equation in cancer patients with raised serum creatinine


1 Department of Basic Sciences, College of Medicine, Princess Noura Bint Abdul Rehman University, Riyadh, Kingdom of Saudi Arabia
2 Institute of Molecular Biology and Biotechnology, University of Lahore, Lahore, Pakistan
3 Shaukat Khanam Memorial Cancer Hospital and Research Center, Lahore, Pakistan

Correspondence Address:
Dr. Amrah Javaid
Department of Basic Sciences, College of Medicine, Princess Noura Bint Abdul Rehman University, Riyadh
Kingdom of Saudi Arabia
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DOI: 10.4103/1319-2442.152422

PMID: 25758877

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To compare the measured glomerular filtration rate (rGFR) using [99mTc] diethylene triamine pentacetic acid (DTPA) clearance or estimated GFR (eGFR) by the Modification of Diet in Renal Disease (MDRD) equation in cancer patients with raised serum creatinine level, we studied 100 cancer patients; 50 patients with normal serum creatinine (control group) and 50 patients with abnormal serum creatinine (study group). History of patients, including site of cancer, chemotherapy regime and dose of chemotherapy, was recorded. The rGFR and eGFR were increased in the study group as compared with the control group, but the GFR recorded by the MDRD formula or DTPA revealed similar values. It is therefore concluded that the MDRD equation may be recommended for eGFR estimation even with abnormal creatinine, without the need for exposure to radiation.


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