Home About us Current issue Back issues Submission Instructions Advertise Contact Login   

Search Article 
  
Advanced search 
 
Saudi Journal of Kidney Diseases and Transplantation
Users online: 426 Home Bookmark this page Print this page Email this page Small font sizeDefault font size Increase font size 
 

Table of Contents   
LETTER TO THE EDITOR  
Year : 2015  |  Volume : 26  |  Issue : 2  |  Page : 368-369
Occult hepatitis C virus infection in dialysis patients: Does it need special attention?


1 Students' Research Committee, Baqiyatallah University of Medical Science; Middle East Liver Disease Center, Tehran, IR Iran
2 Students' Research Committee, Baqiyatallah University of Medical Science, Tehran, IR Iran
3 Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran

Click here for correspondence address and email

Date of Web Publication3-Mar-2015
 

How to cite this article:
Rezaee-Zavareh MS, Ramezani-Binabaj M, Einollahi B. Occult hepatitis C virus infection in dialysis patients: Does it need special attention?. Saudi J Kidney Dis Transpl 2015;26:368-9

How to cite this URL:
Rezaee-Zavareh MS, Ramezani-Binabaj M, Einollahi B. Occult hepatitis C virus infection in dialysis patients: Does it need special attention?. Saudi J Kidney Dis Transpl [serial online] 2015 [cited 2020 Aug 9];26:368-9. Available from: http://www.sjkdt.org/text.asp?2015/26/2/368/152523
To the Editor,

We read with much interest the article by Dr. Khedmat and his colleagues entitled " Hepatitis C Virus Infection in Dialysis Patients" published in your prestigious journal. [1] Diagnosis, course and especially treatment of acute and chronic types of hepatitis C virus (HCV) infections in dialysis patients were investigated in this review article. A new type of HCV infection, called occult hepatitis C infection (OCI), has been introduced in databases, and we would like to add some points about the existence of this type of infection in hemodialysis (HD) patients.

OCI is defined by the presence of HCV RNA in the hepatocytes without detectable serum anti-HCV antibodies and viral RNA by usual laboratory tests. When liver biopsy is not available for determining HCV-RNA in the hepatocytes (i.e., gold standard method for the diagnosis of OCI), detection of HCV-RNA in ultra-centrifuged serum and in peripheral blood mono-nuclear cells can be used as an alternative diagnostic technique. [2] Minimal liver changes, liver cirrhosis and also liver carcinoma are the different reported effects of OCI on liver tissue. Until now, OCI has been reported in different groups such as family members of OCI patients, cryptogenic liver cases and even healthy people. [2],[3]

There are also some reports of OCI in HD patients. [4] Barril et al, with evaluation of 109 HD patients with abnormal liver enzyme, revealed that prevalence of OCI may be high in these patients. In addition, they showed that OCI can be a risk factor for mortality of HD patients. [5] It is also said that both occult and non-occult HCV infection are even more common than hepatitis B infection in HD patients. [6],[7] In a recently published study, however, Baid-Agrawal et al reported that the prevalence of OCI is very low in chronic HD patients. [8]

These data recommend evaluation of OCI in HD patients as a screening method for improving the outcome of HD and kidney transplantation. However, it should be taken into account that data about the prevalence of OCI in HD patients and its treatment are limited. On the other hand, it is so clear that controlling HCV infection in HD units can improve the outcome of the HD and the kidney transplant patients. [9] Therefore, further future clinical studies are still needed to clarify the effects of OCI on the HD patients.

Conflict of interest: None.

Author's Reply

Reply from the authors is awaited.

 
   References Top

1.
Khedmat H, Amini M, Ghamar-Chehreh ME, Agah S. Hepatitis C virus infection in dialysis patients. Saudi J Kidney Dis Transpl 2014; 25:1-8.  Back to cited text no. 1
[PUBMED]  Medknow Journal  
2.
Bokharaei-Salim F, Keyvani H, Monavari SH, et al. Occult hepatitis C virus infection in Iranian patients with cryptogenic liver disease. J Med Virol 2011;83:989-95.  Back to cited text no. 2
    
3.
Carreno V, Bartolome J, Castillo I, Quiroga JA. New perspectives in occult hepatitis C virus infection. World J Gastroenterol 2012; 18:2887-94.  Back to cited text no. 3
    
4.
Thongsawat S, Maneekarn N, Kuniholm MH, et al. Occult hepatitis C virus infection during an outbreak in a hemodialysis unit in Thailand. J Med Virol 2008;80:808-15.  Back to cited text no. 4
    
5.
Barril G, Castillo I, Arenas MD, et al. Occult hepatitis C virus infection among hemodialysis patients. J Am Soc Nephrol 2008;19:2288-92.  Back to cited text no. 5
    
6.
Yakaryilmaz F, Gurbuz OA, Guliter S, et al. Prevalence of occult hepatitis B and hepatitis C virus infections in Turkish hemodialysis patients. Ren Fail 2006;28:729-35.  Back to cited text no. 6
    
7.
Jain P, Nijhawan S. Occult hepatitis C virus infection is more common than hepatitis B infection in maintenance hemodialysis patients. World J Gastroenterol 2008;14:2288-9.  Back to cited text no. 7
    
8.
Baid-Agrawal S, Schindler R, Reinke P, et al. Prevalence of Occult Hepatitis C Infection in Chronic Hemodialysis and Kidney Transplant Patients. J Hepatol 2014;60:928-33.  Back to cited text no. 8
    
9.
Alavian SM. Diabetes, renal failure and hepatitis C infection: The puzzle should be attended more in future. Nephrol Urol Mon 2011;03:153-4.  Back to cited text no. 9
    

Top
Correspondence Address:
Dr. Mahdi Ramezani-Binabaj
Students' Research Committee, Baqiyatallah University of Medical Science, Tehran
IR Iran
Login to access the Email id


DOI: 10.4103/1319-2442.152523

PMID: 25758893

Rights and Permissions




 

Top
   
 
 
    Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
    Email Alert *
    Add to My List *
* Registration required (free)  
 


 
    References
 

 Article Access Statistics
    Viewed2380    
    Printed16    
    Emailed0    
    PDF Downloaded315    
    Comments [Add]    

Recommend this journal