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Saudi Journal of Kidney Diseases and Transplantation
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CASE REPORT Table of Contents   
Year : 2016  |  Volume : 27  |  Issue : 2  |  Page : 407-410
Quadriparesis due to Gitelman's syndrome diagnosed with thiazide diuretic test response


Department of Internal Medicine, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India

Correspondence Address:
Sumanto Mukhopadhyay
Department of Internal Medicine, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal
India
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DOI: 10.4103/1319-2442.178584

PMID: 26997401

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Gitelman's syndrome is characterized by hypocalciuria, severe hypomagnesemia, and prominent muscular involvements such as fatigue, weakness, cramps, and tetany. It is due to mutations in the thiazide sensitive NaCl co-transporter in the distal convoluted tubule. The administration of thiazide diuretics may induce a subnormal increase of urinary Cl excretion in patients with Gitelman's syndrome, consistent with the hypothesis that less than normal Cl is reabsorbed by the thiazide-inhibitable transporter in Gitelman's syndrome. Thus, we report a case of Gitelman's syndrome presenting with quadriparesis diagnosed by using thiazide clearance test.


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