Home About us Current issue Back issues Submission Instructions Advertise Contact Login   

Search Article 
  
Advanced search 
 
Saudi Journal of Kidney Diseases and Transplantation
Users online: 5336 Home Bookmark this page Print this page Email this page Small font sizeDefault font size Increase font size 

RENAL DATA FROM ASIA - AFRICA Table of Contents   
Year : 2016  |  Volume : 27  |  Issue : 6  |  Page : 1217-1223
Proteinuria, graft outcomes, and cardiovascular risk among kidney transplant recipients in a South African Public Hospital


1 Division of Nephrology, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa; Department of Medicine, Yariman Bakura Specialist Hospital, Gusau, Nigeria
2 Division of Nephrology, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa
3 Division of Cardiology, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa

Correspondence Address:
Aminu Muhammad Sakajiki
Department of Medicine, Yariman Bakura Specialist Hospital, PMB 1010, Gusau, Zamfara State, Nigeria

Login to access the Email id


DOI: 10.4103/1319-2442.194655

PMID: 27900969

Rights and Permissions

Proteinuria is a marker of poor long-term graft survival and an independent risk factor for total and cardiovascular mortality in the transplant population. We investigated the prevalence of proteinuria and its relationship with graft function and cardiovascular risk factors in kidney transplant recipients (KTRs). Adult KTRs at the Charlotte Maxeke Johannesburg Academic Hospital were recruited. Patients' records were reviewed for information on their posttransplant follow-up. Echocardiography and carotid Doppler were performed for the assessment of cardiac status and carotid intima-media thickness (CIMT), respectively. Proteinuria was analyzed both as a categorical and continuous variable. Graft dysfunction was defined as estimated glomerular filtration rate of <60 mL/min/1.73 m 2 based on the modification of diet in renal disease formula. Framingham's risk score was used to categorize patients' cardiovascular risk. Inferential and modeling statistics were applied as appropriate using Statistical Package for Social Sciences, and P ≤0.05 was considered statistically significant. One hundred KTRs including 63% males were recruited. Proteinuria was present in 51%, the mean ± standard deviation 24 h urinary protein excretion per day was 1.67 ± 2.0 g/day with a range of 0.4-9.4 g/day. Graft dysfunction was found in 52% of patients and 36% had high cardiovascular disease (CVD) risk. Proteinuric KTRs had high CVD risk, P = 0.002. Proteinuria was associated with graft dysfunction, increased left ventricular mass index, increased CIMT, and anemia. Proteinuria is prevalent; it is a marker of graft dysfunction and is associated with markers of atherosclerosis.


[FULL TEXT] [PDF]*
Print this article  Email this article
    

  Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
   Citation Manager
  Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed943    
    Printed9    
    Emailed0    
    PDF Downloaded134    
    Comments [Add]    

Recommend this journal