Home About us Current issue Back issues Submission Instructions Advertise Contact Login   

Search Article 
  
Advanced search 
 
Saudi Journal of Kidney Diseases and Transplantation
Users online: 11237 Home Bookmark this page Print this page Email this page Small font sizeDefault font size Increase font size 

RENAL DATA FROM ASIA - AFRICA Table of Contents   
Year : 2016  |  Volume : 27  |  Issue : 6  |  Page : 1224-1230
Clinical features and histological patterns of lupus nephritis in a single center of South India


1 Department of Pathology, M. S. Ramaiah Medical College and Hospitals, Bengaluru, Karnataka, India
2 Department of Nephrology, M. S. Ramaiah Medical College and Hospitals, Bengaluru, Karnataka, India

Correspondence Address:
Clement Wilfred Devadass
Department of Pathology, M. S. Ramaiah Medical College and Hospitals, Bengaluru - 560 060, Karnataka
India
Login to access the Email id


DOI: 10.4103/1319-2442.194657

PMID: 27900970

Rights and Permissions

Renal involvement occurs in up to 60% of patients with systemic lupus erythematosus (SLE) and signifies a poor prognosis. The class of lupus nephritis (LN), determined on renal biopsy evaluation, guides the therapeutic management and has prognostic connotations. Our aim is to determine the clinicolaboratory features and histopathological patterns of LN at presentation in our local (South Indian) population. The study was conducted in a tertiary care hospital in South India between 2009 and 2014 on SLE patients with clinical evidence of LN. The renal biopsies were examined by light and immunofluorescence microscopy and were classified according to the International Society of Nephrology/Renal Pathology Society Classification of LN. A total of 46 patients were included, with age range of 12-60 years and a female to male ratio of 8.2:1. Arthritis, dermatological manifestations, and fever occurred, respectively, in 43.5%, 39.1%, and 30.4% of the cases. Class IV LN was present in 17 (37.1%), Class III LN in ten (21.7%), Class II LN in nine (19.5%), Class V LN in eight (17.4%), Class I LN in one (2.2%), and Class VI LN in one (2.2%) patients. Antinuclear antibody (ANA) and dsDNA positivity were present, respectively, in 82.6% and 65.2% of the patients. The most common pattern of LN was Class IV LN followed by Class III LN. Relatively higher proportions of ANA and anti-dsDNA positivity were present in proliferative LN, and there was a high frequency of arthritis at presentation in our LN patients.


[FULL TEXT] [PDF]*
Print this article  Email this article
    

  Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
   Citation Manager
  Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2017    
    Printed12    
    Emailed0    
    PDF Downloaded331    
    Comments [Add]    

Recommend this journal