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Saudi Journal of Kidney Diseases and Transplantation
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Year : 2017  |  Volume : 28  |  Issue : 3  |  Page : 566-570
A randomized controlled trial of the effects of hydrochlorothiazide on overactive bladder and idiopathic hypercalciuria


1 Department of Pediatric Nephrology, Arak University of Medical Sciences, Arak, Iran
2 Department of Pediatrics, Arak University of Medical Sciences, Arak, Iran
3 Department of Biostatistics, Arak University of Medical Sciences, Arak, Iran
4 Department of Basic Sciences, Clinical Research Office, Amir Almomenin Hospital, Arak University of Medical Sciences, Arak, Iran
5 Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran

Correspondence Address:
Mahdyieh Naziri
Department of Base Science, Clinical Research Office, Amir AlMomenin Hospital, Arak University of Medical Sciences, Arak
Iran
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DOI: 10.4103/1319-2442.206458

PMID: 28540894

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Overactive bladder is a stressful condition which affects around 15%—20% of 5- year-old and up to 2% of young adults. One of the most common causes of overactive bladder is hypercalciuria. Our study investigated the effect of hydrochlorothiazide (HCTZ) on overactive bladder and hypercalciuria. This randomized controlled trial was conducted on 88 patients with overactive bladder and idiopathic hypercalciuria. They were randomly divided into the intervention group receiving 1 mg/kg/day of HCTZ for 3 months, and the control group receiving training without any intervention. Treatment compliance and response were reviewed monthly in each patient using a 30-day bedwetting diary. In the 1st month, the mean of bedwetting was 14.47 ± 7.06 and 12.61 ± 7.57 in the intervention and control groups, respectively (P = 0.23). In the 2nd month, it was 10.04 ± 6.32 and 10.79 ± 7.83 in the intervention and control groups, respectively (P = 0.62); and in the 3rd month, it was 6.49 ± 7.13 and 7.64 ± 7.95 in the intervention and control groups, respectively (P = 0.59). There was no significant difference between the two groups. Thus, use of HCTZ was not found to be better than urine retention control training. Therefore, one may conclude that treating hypercalciuria with HCTZ had no demonstrable effect on overactive bladder.


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