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Saudi Journal of Kidney Diseases and Transplantation
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ORIGINAL ARTICLE Table of Contents   
Year : 2017  |  Volume : 28  |  Issue : 4  |  Page : 725-736
Apoptosis of rat renal cells by organophosphate pesticide, quinalphos: Ultrastructural study


Department of Pathology, Electron Microscopy Unit, Faculty of Medicine, King Khalid University, Abha, Saudi Arabia

Correspondence Address:
Refaat A Eid
Department of Pathology, Electron Microscope Unit, College of Medicine, King Khalid University, P. O. Box 641, Abha
Saudi Arabia
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PMID: 28748873

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Quinalphos or Ekalux, an organophosphate pesticide, is used in controlling the pests of a variety of crops. Quinalphos was studied on male Sprague-Dawley albino rats. The acute po LD50 of technical Ekalux was 19.95 mg/kg in males. Ekalux, produced several pathological changes in the kidney. A glomerulus demonstrated capillary lumina occluded by degenerated cellular debris. Basement membrane showed irregular wrinkling and branching. The proximal tubular cells showed damage such as dilation of endoplasmic reticulum, accumulation of glycogen granules, and pyknotic nucleus. The changes also included swelling of the mitochondria and reduction of the cristae up to total destruction. The distal tubular changes included electron lucency and vacuolation of cytoplasm. The distal convoluted tubule wall showed edematous epithelial cells, formation of blebs, and microvilli loss. These results suggest that subchronic exposure of rats to Ekalux causes ultrastructural changes in renal corpuscle and marked ultrastructural changes in proximal and distal tubules.


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