Home About us Current issue Back issues Submission Instructions Advertise Contact Login   

Search Article 
Advanced search 
Saudi Journal of Kidney Diseases and Transplantation
Users online: 901 Home Bookmark this page Print this page Email this page Small font sizeDefault font size Increase font size 

RENAL DATA FROM ASIA - AFRICA Table of Contents   
Year : 2017  |  Volume : 28  |  Issue : 4  |  Page : 869-873
Prevalence of Hepatitis B core antibodies with negative Hepatitis B surface antigen in dialysis and chronic kidney disease patients

1 Department of Medicine, Division of Nephrology, Fatima Memorial Hospital, University of Health Sciences, Lahore, Pakistan
2 Department of Pathology, Fatima Memorial Hospital, University of Health Sciences, Lahore, Pakistan

Correspondence Address:
Nauman Tarif
Division of Nephrology, Department of Medicine, Fatima Memorial Hospital, University of Health Sciences, Lahore
Login to access the Email id

PMID: 28748890

Rights and Permissions

Occult hepatitis B infection (OBI) is a potential cause of infection transmission in patients with chronic kidney disease (CKD) and dialysis-dependant patients. It is liable to be missed since the marker for OBI, hepatitis B core antibody (HBcAb), is not done routinely. We carried out a study to assess the prevalence of OBI in CKD Stage II–V or requiring renal replacement therapy. It was a cross-sectional study carried out at Fatima Memorial Hospital, Lahore, from May 2104 to May 2015. A total of 188 patients were included in this study, 124 were dialysis dependent and 64 had acute or CKD Stage II–V. About 17.55% (n = 33) of patients had isolated HBcAb positive. Nearly 33.5% (n = 63) of patients were found to have hepatitis B surface antigen positive, indicating development of immunity by exposure to virus. About 20.74% (n = 39) of patients were co-positive with HBcAb also. The prevalence of isolated HBcAb in dialysis and CKD patients is high; therefore, testing for HBcAb should be a routine part of screening in our CKD population to rule out OBI. Further confirmation with polymerase chain reaction analysis for HBV viral DNA is recommended. Considering our circumstances, a consensus statement from the hepatologists and nephrologists is needed to further plan for the management of such cases.

Print this article  Email this article

  Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
   Citation Manager
  Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded315    
    Comments [Add]    

Recommend this journal