Home About us Current issue Back issues Submission Instructions Advertise Contact Login   

Search Article 
  
Advanced search 
 
Saudi Journal of Kidney Diseases and Transplantation
Users online: 341 Home Bookmark this page Print this page Email this page Small font sizeDefault font size Increase font size 

CASE REPORT Table of Contents   
Year : 2017  |  Volume : 28  |  Issue : 6  |  Page : 1416-1420
Fibronectin glomerulopathy - A sporadic case with unusual clinical manifestation


1 Department of Nephrology, NH Malla Reddy Narayana Multispeciality Hospital, Telangana, Hyderabad, India
2 Department of Histopathology, Apollo Hospital, Telangana, Hyderabad, India
3 Laboratory of Immunology and Genetics of Transplantation and Rare Diseases IRCCS - “Mario Negri” Institute for Pharmacological Research Ranica, Bergamo, Italy
4 Department of Pathology, Apollo Hospital, Telangana, Hyderabad, India

Correspondence Address:
Surya Narayan Mandal
Department of Nephrology, NH Malla Reddy Narayana Multispeciality Hospital, Telangana, Hyderabad
India
Login to access the Email id


DOI: 10.4103/1319-2442.220860

PMID: 29265057

Rights and Permissions

A 22-year-old nondiabetic young Indian female presented with short history of dyspnea, anorexia, and bilateral leg swelling. Her laboratory evaluation showed severe anemia, serum creatinine of 11.89 mg/dL, nephrotic range proteinuria and microscopic hematuria with 6–8 red blood cell/high-power field. Renal biopsy showed brightly eosinophilic, periodic acid-Schiff (PAS) positive, silver negative, and fuschinophilic deposits in the mesangium extending around the capillary loops with thickening of the basement membrane. Immunohistochemistry was strongly positive for fibronectin (FN). There was no family history of renal disease. Genetic screening revealed absence of mutations in the FN1 gene. She was put on maintenance hemodialysis.


[FULL TEXT] [PDF]*
Print this article  Email this article
    

  Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
   Citation Manager
  Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1147    
    Printed11    
    Emailed0    
    PDF Downloaded112    
    Comments [Add]    

Recommend this journal