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Saudi Journal of Kidney Diseases and Transplantation
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Table of Contents   
LETTER TO THE EDITOR  
Year : 2017  |  Volume : 28  |  Issue : 6  |  Page : 1451-1452
The role of supplements in reducing cardiovascular events by decrease in highly sensitive C-reactive protein and serum homocysteine


Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

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Date of Web Publication18-Dec-2017
 

How to cite this article:
Lotfiazar A, Einollahi B. The role of supplements in reducing cardiovascular events by decrease in highly sensitive C-reactive protein and serum homocysteine. Saudi J Kidney Dis Transpl 2017;28:1451-2

How to cite this URL:
Lotfiazar A, Einollahi B. The role of supplements in reducing cardiovascular events by decrease in highly sensitive C-reactive protein and serum homocysteine. Saudi J Kidney Dis Transpl [serial online] 2017 [cited 2019 Dec 7];28:1451-2. Available from: http://www.sjkdt.org/text.asp?2017/28/6/1451/220853


To the Editor,

We read with interest the article entitled “The Relationship between Serum Homocysteine and Highly Sensitive C-reactive Protein (HSCRP) Levels in Children on Regular Hemodialysis” published in your esteemed journal.[1]

In this study, Abdel-Salam et al reported that the HSCRP and serum homocysteine are cardiovascular risk predictors. Furthermore, they found a significant relationship between HSCRP and serum homocysteine and blood pressure, cholesterol, triglyceride, parathormone, and ferritin levels.[1]

We studied the role of Vitamin C and Vitamin B12 in patients with end-stage renal disease (ESRD) to reduce the level of HSCRP and serum homocysteine, respectively.[2],[3] In addition, Mirchi et al evaluated the level of 25-hydroxyvitamin D3 in hemodialysis patients and its relationship with HSCRP.[4] Interestingly, there was a significant correlation between the serum Vitamin D level and inflammatory factors such as HSCRP and neutrophil-lymphocyte ration.[4] Furthermore, there were some positive results with Group B vitamins and Vitamin E coated dialyzer in some studies about the inflammatory factors;[3],[5],[6] however, there was no considerable effect for Vitamin K and A.

Thus, based on previous researches, water-soluble supplements, Vitamin D and Vitamin E could be useful for ESRD patients to prevent the risk of brain stroke, myocardial infarction, and peripheral vascular disease by reduction in inflammatory agents.[7],[8],[9]

Finally, the role of supplements must be considered in ESRD patients to reduce the cardiovascular complications.

Conflict of interest: None declared.



 
   References Top

1.
Abdel-Salam M, Ibrahim S, Pessar SA, Al-Morsy E. The relationship between serum homocysteine and highly sensitive C-reactive protein levels in children on regular hemodialysis. Saudi J Kidney Dis Transpl 2017; 28:483-90.  Back to cited text no. 1
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2.
Biniaz V, Sadeghi Shermeh M, Ebadi A, Tayebi A, Einollahi B. Effect of Vitamin C supplementation on C-reactive protein levels in patients undergoing hemodialysis: A Randomized, double blind, placebo-controlled study. Nephrourol Mon 2014;6:e13351.  Back to cited text no. 2
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3.
Tayebi A, Biniaz V, Savari S, et al. Effect of Vitamin B12 supplementation on serum homocysteine in patients undergoing hemodialysis: A randomized controlled trial. Saudi J Kidney Dis Transpl 2016;27:256-62.  Back to cited text no. 3
[PUBMED]  [Full text]  
4.
Mirchi E, Saghafi H, Gharehbeglou M, et al. Association between 25-hydroxyvitamin D level and inflammatory and nutritional factors in hemodialysis and peritoneal dialysis patients in qom, Iran. Iran J Kidney Dis 2016;10:205-12.  Back to cited text no. 4
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5.
Takouli L, Hadjiyannakos D, Metaxaki P, et al. Vitamin E-coated cellulose acetate dialysis membrane: Long-term effect on inflammation and oxidative stress. Ren Fail 2010;32:287-93.  Back to cited text no. 5
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6.
Deved V, Poyah P, James MT, et al. Ascorbic acid for anemia management in hemodialysis patients: A systematic review and meta-analysis. Am J Kidney Dis 2009;54:1089-97.  Back to cited text no. 6
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7.
Mendall MA, Strachan DP, Butland BK, et al. C-reactive protein: Relation to total mortality, cardiovascular mortality and cardiovascular risk factors in men. Eur Heart J 2000;21: 1584-90.  Back to cited text no. 7
    
8.
Kuller LH, Tracy RP, Shaten J, Meilahn EN. Relation of C-reactive protein and coronary heart disease in the MRFIT nested case-control study. Multiple risk factor intervention trial. Am J Epidemiol 1996;144:537-47.  Back to cited text no. 8
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9.
Danesh J, Whincup P, Walker M, et al. Low grade inflammation and coronary heart disease: Prospective study and updated metaanalyses. BMJ 2000;321:199-204.  Back to cited text no. 9
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Correspondence Address:
Aidin Lotfiazar
Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran
Iran
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DOI: 10.4103/1319-2442.220853

PMID: 29265067

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