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Saudi Journal of Kidney Diseases and Transplantation
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Year : 2017  |  Volume : 28  |  Issue : 6  |  Page : 1455
Milk-alkali syndrome and influenza vaccination

1 KMT Primary Care Center, Bangkok, Thailand
2 Hainan Medical University, Haikou, China

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Date of Web Publication18-Dec-2017

How to cite this article:
Yasri S, Wiwanitkit V. Milk-alkali syndrome and influenza vaccination. Saudi J Kidney Dis Transpl 2017;28:1455

How to cite this URL:
Yasri S, Wiwanitkit V. Milk-alkali syndrome and influenza vaccination. Saudi J Kidney Dis Transpl [serial online] 2017 [cited 2020 Jul 2];28:1455. Available from: http://www.sjkdt.org/text.asp?2017/28/6/1455/220861

To the Editor,

The report on “milk-alkali syndrome and influenza vaccination” by Al-Hwiesh et al is very interesting.[1] Al-Hwiesh et al mentioned that “The available literatures indicate that influenza vaccine may cause fever and myalgias in the elderly, but no relation between H1N1-influenza vaccination and milkalkali syndrome (MAS) has been yet reported; a subject that needs further workup.”[1] In fact, the adverse effect due to the influenza vaccination is an important concern since the vaccination is usually recommended to the elderly including to those with underlying renal problem. Al-Hwiesh et al proposed “the possibility of the vaccine-induced MAS either through interferences with calcium excretion (like thiazide diuretic effect) or by decreasing calcium excretion through enhancing tubular reabsorption or both.”[1] Indeed, the disturbance of calcium metabolism and excretion is an important metabolic problem reported as uncommon adverse effect due to several vaccinations including hepatitis B vaccination.[2] For the influenza vaccine, there is no specific report in human, but there is already a report on the problem of metabolic disturbance that results in death in animals receiving influenza vaccine.[3]

Conflict of interest: None declared.

   References Top

Al-Hwiesh AK, Abdul-Rahman IS, Al-Oudah N, Al-Solami S, Al-Muhanna FA. Milk-Alkali syndrome induced by H1N1 influenza vaccine. Saudi J Kidney Dis Transpl 2017;28:912-5.  Back to cited text no. 1
[PUBMED]  [Full text]  
Cathebras P, Cartry O, Lafage-Proust MH, et al. Arthritis, hypercalcemia, and lytic bone lesions after hepatitis B vaccination. J Rheumatol 1996;23:558-60.  Back to cited text no. 2
Swayne DE, Radin MJ, Hoepf TM, Slemons RD. Acute renal failure as the cause of death in chickens following intravenous inoculation with avian influenza virus A/chicken/Alabama/ 7395/75 (H4N8). Avian Dis 1994;38:151-7.  Back to cited text no. 3

Correspondence Address:
Sora Yasri
KMT Primary Care Center, Bangkok
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DOI: 10.4103/1319-2442.220861

PMID: 29265070

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