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Saudi Journal of Kidney Diseases and Transplantation
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Year : 2018  |  Volume : 29  |  Issue : 3  |  Page : 747-748
Interleukin-6 -174G/C polymorphism and end-stage renal disease: Is there any role?

1 RVT 1 Medical Center, Bangkok, Thailand
2 Hainan Medical University, Haikou, China

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Date of Submission29-May-2017
Date of Acceptance13-Feb-2018
Date of Web Publication28-Jun-2018

How to cite this article:
Srriwijitalai W, Wiwanitkit V. Interleukin-6 -174G/C polymorphism and end-stage renal disease: Is there any role?. Saudi J Kidney Dis Transpl 2018;29:747-8

How to cite this URL:
Srriwijitalai W, Wiwanitkit V. Interleukin-6 -174G/C polymorphism and end-stage renal disease: Is there any role?. Saudi J Kidney Dis Transpl [serial online] 2018 [cited 2019 Oct 14];29:747-8. Available from: http://www.sjkdt.org/text.asp?2018/29/3/747/235202
To the Editor,

The genetic underlying of end-stage kidney disease (ESRD) is a very interesting topic. Of several genetic factors, the effect of polymorphism is usually mentioned.

The interleukin-6 (IL-6) -174G/C polymorphism is a widely studied for the association with ESRD.

In fact, as Zahed and Chehrazi. reported in their article, the IL-6 was associated with some metabolic disturbance and might affect the renal of the patients.[1] However, the interesting concern is on the effect of different genetic forms, polymorphism, of IL-6. Several reports show different findings on effects of genetic polymorphism of IL-6 in different populations.[2],[3],[4],[5] There is a recent publication on meta-analysis on this topic by Feng et al.[6] Feng et al concluded for no effect of IL-6-174G/C polymorphism on ESRD. Nevertheless, Feng et al. still concerned on the selection bias in their study and proposed that “the conclusion still needs to be further confirmed by more large-sample, multicenter, and high quality case-control studies, for providing a theoretical basis for clarifying the function of IL-6 gene polymorphism in the pathogenesis of ESRD.”[5] Here, the authors used standard bioinformatics gene ontology study to simulate and study the effect of G/C polymorphism on the expression of IL-6. This technique is simple standard technique as used in the previous reports.[7],[8],[9] Based on the gene ontology analysis, no change of biological process due to G/C polymorphism was observed. Hence, it is concordant with the meta-analysis by Feng et al.[6] Hence, the conclusion that there is no effect of IL-6-174G/C polymorphism on ESRD can be repeatedly confirmed.

Conflict of interest: None declared.

Author's Reply

Reply from the authors is awaited.

   References Top

Zahed NS, Chehrazi S. The evaluation of the relationship between serum levels of interleukin-6 and interleukin-10 and metabolic acidosis in hemodialysis patients. Saudi J Kidney Dis Transpl 2017;28:23-9.  Back to cited text no. 1
[PUBMED]  [Full text]  
Cox ED, Hoffmann SC, DiMercurio BS, et al. Cytokine polymorphic analyses indicate ethnic differences in the allelic distribution of interleukin-2 and interleukin-6. Transplantation 2001;72:720-6.  Back to cited text no. 2
Akira S, Taga T, Kishimoto T. Interleukin-6 in biology and medicine. Adv Immunol 1993; 54:1-78.  Back to cited text no. 3
Aker S, Bantis C, Reis P, et al. Influence of interleukin-6 G-174C gene polymorphism on coronary artery disease, cardiovascular complications and mortality in dialysis patients. Nephrol Dial Transplant 2009;24:2847-51.  Back to cited text no. 4
Chow KM, Wong TY, Li PK. Genetics of common progressive renal disease. Kidney Int Suppl 2005;67:S41-5.  Back to cited text no. 5
Feng Y, Tang Y, Zhou H, Xie K. A metaanalysis on correlation between interleukin-6-174G/C polymorphism and end-stage renal disease. Ren Fail 2017;39:350-6.  Back to cited text no. 6
Wiwanitkit V. CAG repeat polymorphism in the androgen receptor: A study on the effect of different numbers of repeats using gene ontology technique. Fertil Steril 2009;91:e5-6.  Back to cited text no. 7
Wiwanitkit V. I/D genetic polymorphism of angiotensin-converting enzyme: Pathogenesis evaluation for erectile dysfunction by gene ontology. Fertil Steril 2008;89:1095-7.  Back to cited text no. 8
Wiwanitkit V. IgA-CD89 complex in IgA nephropathy: A study on molecular function. Ren Fail 2006;28:457-9.  Back to cited text no. 9

Correspondence Address:
Dr. Won Srriwijitalai
RVT 1 Medical Center, Bangkok
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DOI: 10.4103/1319-2442.235202

PMID: 29970762

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