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Saudi Journal of Kidney Diseases and Transplantation
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ORIGINAL ARTICLE Table of Contents   
Year : 2019  |  Volume : 30  |  Issue : 2  |  Page : 334-338
Seroconversion following hepatitis B vaccination in children with chronic kidney disease


Department of Pediatric Nephrology, St. John's Medical College Hospital, Bengaluru, Karnataka, India

Correspondence Address:
Nivedita Kamath
Department of Pediatric Nephrology, St. John's Medical College, Sarjapur Road, Bengaluru - 560 034, Karnataka
India
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DOI: 10.4103/1319-2442.256840

PMID: 31031369

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Seroconversion following hepatitis B vaccination is low in children with chronic kidney disease (CKD). This study aimed to assess the seroconversion and persistence of protective immunity following hepatitis B vaccination in children with CKD. This prospective observational study was conducted in a tertiary pediatric nephrology centre to assess the seroconversion and maintenance of antibody titers (>10 mIU/mL) at one year following hepatitis B vaccination (10 μg at 0, 1, and 2 months) in children with CKD Stages II to V. Those who did not seroconvert after the schedule were re-vaccinated, and antibody titers were checked. Categorical data were expressed as proportions and analyzed using the Chi-square test. Pearson’s correlation test was used to determine the correlation of antibody titers with other continuous variables. Seroconversion was observed in 72% (n = 26/36) after vaccination. Only 60% (n = 6/10) had seroconversion after the second course of vaccination. Only 60% of children (n = 12/20) who seroconverted had protective antibody titers at one year. Seroconversion following three doses of hepatitis B vaccine is low in children with CKD. Antibody titers should be monitored periodically as the protective immunity wanes rapidly.


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