Saudi Journal of Kidney Diseases and Transplantation

ORIGINAL ARTICLE
Year
: 1995  |  Volume : 6  |  Issue : 2  |  Page : 183--189

Impact of Hepatitis C Virus Infection on Kidney Transplant Outcome


Osman I Alfurayh1, Mohamed A.E Sobh1, Tariq S Chaudry1, Wajeh Y Qunibi1, Khalid Al Meshari1, Michael Ellis1, Mohamed A Ali2, Saadi Taher1 
1 Department of Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
2 Department of Pathology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia

Correspondence Address:
Osman I Alfurayh
Department of Medicine, King Faisal Specialist Hospital and Research Center, P.O. Box 3354, Riyadh 11211
Saudi Arabia

One hundred and forty kidney transplant recipients were evaluated to study the impact of hepatitis C virus (HCV) infection on patient and graft outcome. There .were 98 males arid 42 females with a mean age of 32.1 13 years. The duration of follow-up ranged from 6-60 months with a mean period of 27.8 18.2 months. Seventy-four (53%) patients had received cadaveric kidneys while 66 (47%) received living donor grafts. Anti-HCV reactivity was tested using second generation enzyme-linked immunosorbent assay and positivity was confirmed by recombinant immunoblot assay. HCV infection was diagnosed in 29 cases (20.7%) while HBsAg was found in nine (6.4%) and concomitant anti-HCV and HBsAg positivity was observed in two patients (1.4%). Seventeen of 29 (58.6%) patients with anti-HCV reactivity showed elevated ALT levels as against 17 of 111 (17.3%) anti-HCV non-reactive patients (P<0.001). There was no association between the sex of the patient, source of the graft, and anti-HCV reactivity. Serum creatinine values were higher in the anti-HCV positive group, but this did not rank to statistical significance. We observed a significantly higher graft loss among the anti-HCV reactive group (27.6% versus 1.8%, P< 0.003). Thirteen anti-HCV reactive patients were subjected to 18 liver biopsies; the commonest lesion observed was chronic active hepatitis, which was progressive in two patients subjected to re-biopsy. We conclude that HCV infection is a serious health problem among kidney transplant recipients and it significantly affects the graft outcome.


How to cite this article:
Alfurayh OI, Sobh MA, Chaudry TS, Qunibi WY, Al Meshari K, Ellis M, Ali MA, Taher S. Impact of Hepatitis C Virus Infection on Kidney Transplant Outcome.Saudi J Kidney Dis Transpl 1995;6:183-189


How to cite this URL:
Alfurayh OI, Sobh MA, Chaudry TS, Qunibi WY, Al Meshari K, Ellis M, Ali MA, Taher S. Impact of Hepatitis C Virus Infection on Kidney Transplant Outcome. Saudi J Kidney Dis Transpl [serial online] 1995 [cited 2020 Mar 29 ];6:183-189
Available from: http://www.sjkdt.org/article.asp?issn=1319-2442;year=1995;volume=6;issue=2;spage=183;epage=189;aulast=Alfurayh;type=0