Saudi Journal of Kidney Diseases and Transplantation

CASE REPORT
Year
: 2008  |  Volume : 19  |  Issue : 5  |  Page : 796--798

Vitamin D Dependent Rickets Type II: Late Onset of Disease and Response to High Doses of Vitamin D


Sachin S Soni, Gopal Kishan Adikey, Anuradha S Raman 
 Department of Nephrology, Mediciti Hospitals, Hyderabad, Andhra Pradesh, India

Correspondence Address:
Anuradha S Raman
Department of Nephrology, Mediciti Hospitals, 5-9-22, Secretariat Road, Hyderabad, Andhra Pradesh, 500063
India

Vitamin D dependent rickets Type II is a rare autosomal recessive disorder. The disorder is characterized by end organ hyporesponsiveness to vitamin D. Common presentation of the disorder is total body alopecia and onset of rickets during the second half of the first year of life. Patients may display progressive rachitic bone changes, hypocalcemia and secondary hyper­parathyroidism. It is differentiated from vitamin D dependent rickets type I by virtue of response to physiological doses of exogenous vitamin D in the later. Target organ hyporesponsiveness can be overcome by higher doses of vitamin D or its analogues. We report a case of vitamin D dependent rickets type II with onset of rickets at the age of thirteen years without alopecia progressing to marked disability by twenty three years of age. She responded to massive doses of vitamin D with significant clinical improvement after six months of therapy.


How to cite this article:
Soni SS, Adikey GK, Raman AS. Vitamin D Dependent Rickets Type II: Late Onset of Disease and Response to High Doses of Vitamin D.Saudi J Kidney Dis Transpl 2008;19:796-798


How to cite this URL:
Soni SS, Adikey GK, Raman AS. Vitamin D Dependent Rickets Type II: Late Onset of Disease and Response to High Doses of Vitamin D. Saudi J Kidney Dis Transpl [serial online] 2008 [cited 2019 Dec 8 ];19:796-798
Available from: http://www.sjkdt.org/article.asp?issn=1319-2442;year=2008;volume=19;issue=5;spage=796;epage=798;aulast=Soni;type=0