Saudi Journal of Kidney Diseases and Transplantation

RENAL DATA FROM THE ARAB WORLD
Year
: 2008  |  Volume : 19  |  Issue : 5  |  Page : 825--830

Cancers after Renal Transplantation: Multicenter Experience


Kais Harzallah1, Ezzedine Abderrahim2, Khaled Chareffedine3, Soumaya Yeich3, Raoudha Belhadj1, Habib Skhiri4, Fethi Younsi2, Taeib Ben Abdallah2, Achour Abdelletif5, Jamil Hachicha3, Jalel Hmida6, Mezri El May4, Adel Khedr2, Jamel Manaa1 
1 Unity of Organ Transplantation, Military Hospital of Tunis, Tunisia
2 Department of Nephrology, Charles Nicolle Hospital Tunis, Tunisia
3 Department of Nephrology, Hedi Chaker Hospital Sfax, Tunisia
4 Department of Nephrology, Fattouma Bourguiba Hospital Monastir, Tunisia
5 Department of Nephrology, Sahloul Hospital Sousse, Tunisia, Tunisia
6 Unity of Hemodialysis, Military Hospital of Tunis, Tunisia

Correspondence Address:
Kais Harzallah
Unity of Organ Transplantation, Military Hospital of Tunis
Tunisia

Renal transplant recipients are at higher risk of certain tumors such as lymphomas and skin cancers and than the general and dialysis populations. We retrospectively studied the prevalence of tumors in adult renal transplant recipients in four Tunisian centers of transplantation in Tunis, Monsatir and Sfax from January 1986 to January 2005. The study included 36 patients; 19 men and 17 women with a mean age of 34.6 years (range from 18-54 years). The mean time since dialysis to transplantation was 43 months (6-131months). Maintenance therapy was based on calcineurin inhibitors (CNI) in 86 % of cases, on antimetabolites and corticosteroids in 100 % of cases. Anti-thymoglobulin was administered in a mean course of 12.4 days in 78 % of the patients. Acute rejection occurred in 25 cases and was treated with polyclonal or monoclonal antibodies on 40 % of cases. Incidence of cancer among our population was 7 % and occurred after a mean period of 54 months of transplantation (range from 4-160 months). Eighty three percent of the tumors were solid, and the rest were in the skin. Kaposi sarcoma formed 41.6 % and non-Hodgkin or Hodgkin lymphoma 27.7 % of the solid tumors, while spinocellular carcinoma formed 83% and basocellular carcinoma 17% of the skin tumors. Switching CNI to sirolimus in 8.3% cases was associated with a favorable outcome. Mortality was the outcome in 33.3% of the patients with cancer, while partial or complete regression of cancers was observed in 55.5% cases after decreasing the doses of the immunosuppressive medications. We conclude that post renal transplant cancer is mainly characterized by the predominance of Kaposi sarcoma favored by solar exposure and rigorously induced and maintained immunosuppression. Careful follow-up may results in early inter­vention and decrease mortality.


How to cite this article:
Harzallah K, Abderrahim E, Chareffedine K, Yeich S, Belhadj R, Skhiri H, Younsi F, Abdallah TB, Abdelletif A, Hachicha J, Hmida J, El May M, Khedr A, Manaa J. Cancers after Renal Transplantation: Multicenter Experience.Saudi J Kidney Dis Transpl 2008;19:825-830


How to cite this URL:
Harzallah K, Abderrahim E, Chareffedine K, Yeich S, Belhadj R, Skhiri H, Younsi F, Abdallah TB, Abdelletif A, Hachicha J, Hmida J, El May M, Khedr A, Manaa J. Cancers after Renal Transplantation: Multicenter Experience. Saudi J Kidney Dis Transpl [serial online] 2008 [cited 2020 Jul 9 ];19:825-830
Available from: http://www.sjkdt.org/article.asp?issn=1319-2442;year=2008;volume=19;issue=5;spage=825;epage=830;aulast=Harzallah;type=0