Saudi Journal of Kidney Diseases and Transplantation

ORIGINAL ARTICLE
Year
: 2009  |  Volume : 20  |  Issue : 3  |  Page : 443--447

Comparison of 24-hour urinary protein and protein-to-creatinine ratio in the assessment of proteinuria


Ayman M Wahbeh, Mohammad H Ewais, Mahamed E Elsharif 
 Division of Nephrology, Department of Internal Medicine, University of Jordan, Amman, Jordan

Correspondence Address:
Ayman M Wahbeh
Assistant Professor of Medicine, University of Jordan, P.O. Box 1374, Amman 11941
Jordan

To determine the correlation between protein-to-creatinine ratio (PCR) and 24-hour urinary protein (UP), we measured proteinuria in 68 patients attending the nephrology clinic at Jordan University Hospital by 24-hour urine protein excretion and protein-to-creatinine ratio. The cutoff values for spot urine protein-to-creatinine ratio in predicting 24-hour protein «DQ»threshold«DQ» excretion of 0.5, 1.0 and 3.5 g/day were determined using receiver operating characteristic curves. A very good correlation (r= 0.832, P< 0.0001) was found between spot urine protein-to-creatinine ratio and 24-hour urine protein excretion. Bland-Altman plot showed the two tests had reasonable limits of agreement at low level of protein excretion but the limits became wider as the protein excretion increased. For protein excretion < 2.0 g/day, the limits of agreement of spot urine (PCR) and (UP) were +1.48 and -1.2 g/day. The spot urine protein-to-creatinine ratios of 0.72 (sensitivity 0.97; specificity 1.0), 1.2 (0.97; 0.89) and 3.23 (1.0; 0.86) mg/mg reliably predicted 24-hour urine total protein equivalent «DQ»thresholds«DQ» of 0.5, 1.0 and 3.5 g/day, respectively. We conclude that the protein-to-creatinine ratio in spot urine specimens is an accurate, convenient, and reliable method to estimate the protein excretion in urine. However, the protein-to-creatinine ratio will likely be within clinically acceptable limits only when proteinuria is at reasonably low levels.


How to cite this article:
Wahbeh AM, Ewais MH, Elsharif ME. Comparison of 24-hour urinary protein and protein-to-creatinine ratio in the assessment of proteinuria.Saudi J Kidney Dis Transpl 2009;20:443-447


How to cite this URL:
Wahbeh AM, Ewais MH, Elsharif ME. Comparison of 24-hour urinary protein and protein-to-creatinine ratio in the assessment of proteinuria. Saudi J Kidney Dis Transpl [serial online] 2009 [cited 2020 Aug 7 ];20:443-447
Available from: http://www.sjkdt.org/article.asp?issn=1319-2442;year=2009;volume=20;issue=3;spage=443;epage=447;aulast=Wahbeh;type=0