Saudi Journal of Kidney Diseases and Transplantation

ORIGINAL ARTICLE
Year
: 2009  |  Volume : 20  |  Issue : 5  |  Page : 802--805

Outcome of pregnancy in patients with inactive systemic lupus erythromatosus and minimal proteinuria


Saad Alshohaib 
 Department of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia

Correspondence Address:
Saad Alshohaib
Faculty of Medicine, King Abdulaziz University, Jeddah
Saudi Arabia

Systemic lupus erythematosus (SLE) is a multisystem disease. This study was under­taken to assess the outcome of pregnancies in patients with inactive SLE. We prospectively studied 20 female patients with diagnosis of stable class IV Lupus nephritis followed up at King Abdul Aziz University Hospital, in Jeddah, Saudi Arabia between 1998 and 2008. Before each pregnancy all the patients had their blood pressure, serum creatinine, creatinine clearance, serology for SLE and 24-hour urine protein excretion measured and then repeated at monthly intervals during the pregnancy. Statistical analysis was performed using the Wilcoxon signed-rank test. Despite having negative antinuclear antibody (ANA) significant complications were observed during pregnancy. The daily proteinuria during 34-36 weeks«SQ» gestation was significantly higher (P< 0.05) than during 32 weeks. Two patients had abortions one stillbirth and 2 required termination of the pregnancy; one due to severe hypertension, and other due to renal impairment. One patient developed HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome. 14 patients had a successful preg­nancy, including 4 requiring a cesarian section. In conclusion, although no clinical evidence of lupus disease activity was demonstrated pre-conception proteinuria significantly increased during pregnancy along with maternal and fetal complications. Pregnant females with diagnosis of SLE need a multidisciplinary care during the pregnancy and post-partum period.


How to cite this article:
Alshohaib S. Outcome of pregnancy in patients with inactive systemic lupus erythromatosus and minimal proteinuria.Saudi J Kidney Dis Transpl 2009;20:802-805


How to cite this URL:
Alshohaib S. Outcome of pregnancy in patients with inactive systemic lupus erythromatosus and minimal proteinuria. Saudi J Kidney Dis Transpl [serial online] 2009 [cited 2020 Jul 7 ];20:802-805
Available from: http://www.sjkdt.org/article.asp?issn=1319-2442;year=2009;volume=20;issue=5;spage=802;epage=805;aulast=Alshohaib;type=0