Saudi Journal of Kidney Diseases and Transplantation

ORIGINAL ARTICLE
Year
: 2009  |  Volume : 20  |  Issue : 6  |  Page : 1030--1037

Validation of predictive equations for glomerular filtration rate in the Saudi population


Jamal S Al Wakeel1, Durdana Hammad1, Abdulkareem Al Suwaida1, Nauman Tarif1, AbdulRauf Chaudhary2, Arthur Isnani2, Waleed Ahmed Albedaiwi3, Ahmad H Mitwalli1, Shaik Shaffi Ahmad4 
1 Division of Nephrology, Department of Medicine, King Khalid Hospital, King Saud University, Riyadh, Saudi Arabia
2 Division of Nephrology, Research centre, King Khalid Hospital, King Saud University, Riyadh, Saudi Arabia
3 King Fahad National Guard Hospital Riyadh, Saudi Arabia
4 Division of Nephrology, Department of Community Medicine, King Khalid Hospital, King Saud University, Riyadh, Saudi Arabia

Correspondence Address:
Jamal S Al Wakeel
Department of Medicine (38), King Khalid University Hospital, P.O. Box 2925, Riyadh 11461
Saudi Arabia

Predictive equations provide a rapid method of assessing glomerular filtration rate (GFR). To compare the various predictive equations for the measurement of this parameter in the Saudi population, we measured GFR by the Modification of Diet in Renal Disease (MDRD) and Cockcroft-Gault formulas, cystatin C, reciprocal of cystatin C, creatinine clearance, reciprocal of creatinine, and inulin clearance in 32 Saudi subjects with different stages of renal disease. We com-pared GFR measured by inulin clearance and the estimated GFR by the equations. The study included 19 males (59.4%) and 13 (40.6%) females with a mean age of 42.3 ± 15.2 years and weight of 68.6 ± 17.7 kg. The mean serum creatinine was 199 ± 161 μmol/L. The GFR measured by inulin clearance was 50.9 ± 33.5 mL/min, and the estimated by Cockcroft-Gault and by MDRD equations was 56.3 ± 33.3 and 52.8 ± 32.0 mL/min, respectively. The GFR estimated by MDRD revealed the strongest correlation with the measured inulin clearance (r= 0.976, P= 0.0000) followed by the GFR estimated by Cockcroft-Gault, serum cystatin C, and serum creatinine (r= 0.953, P= 0.0000) (r= 0.787, P= 0.0001) (r= -0.678, P= 0.001), respectively. The reciprocal of cystatin C and serum creatinine revealed a correlation coefficient of 0.826 and 0.93, respectively. Cockroft-Gault for­mula overestimated the GFR by 5.40 ± 10.3 mL/min in comparison to the MDRD formula, which exhibited the best correlation with inulin clearance in different genders, age groups, body mass index, renal transplant recipients, chronic kidney disease stages when compared to other GFR predictive equations.


How to cite this article:
Al Wakeel JS, Hammad D, Al Suwaida A, Tarif N, Chaudhary A, Isnani A, Albedaiwi WA, Mitwalli AH, Ahmad SS. Validation of predictive equations for glomerular filtration rate in the Saudi population.Saudi J Kidney Dis Transpl 2009;20:1030-1037


How to cite this URL:
Al Wakeel JS, Hammad D, Al Suwaida A, Tarif N, Chaudhary A, Isnani A, Albedaiwi WA, Mitwalli AH, Ahmad SS. Validation of predictive equations for glomerular filtration rate in the Saudi population. Saudi J Kidney Dis Transpl [serial online] 2009 [cited 2020 Jul 15 ];20:1030-1037
Available from: http://www.sjkdt.org/article.asp?issn=1319-2442;year=2009;volume=20;issue=6;spage=1030;epage=1037;aulast=Al;type=0